GPLD1
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) |
| ||||||||
| Location (UCSC) | Chr 6: 24.42 – 24.5 Mb | Chr 13: 25.13 – 25.18 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene.[5][6]
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a
plasma membrane.[6]
Plasma concentrations of Gpld1 in mice were found to increase after exercise and to correlate with improved
cognitive function, and concentrations of GPLD1 in blood were increased in active elderly humans.[7][8]
Interactions
GPLD1 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112293 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021340 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11072085.
- ^ a b "Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1".
- S2CID 220428681.
- National Public Radio.
- ^ PMID 11254757.
Further reading
- Hoener MC, Brodbeck U (June 1992). "Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins". European Journal of Biochemistry. 206 (3): 747–57. PMID 1606959.
- Scallon BJ, Fung WJ, Tsang TC, Li S, Kado-Fong H, Huang KS, Kochan JP (April 1991). "Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D". Science. 252 (5004): 446–8. PMID 2017684.
- Metz CN, Brunner G, Choi-Muira NH, Nguyen H, Gabrilove J, Caras IW, et al. (April 1994). "Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D". The EMBO Journal. 13 (7): 1741–51. PMID 7512501.
- Jinnai H, Nakamura S (August 1999). "Characterization of phospholipase D activation by GM2 activator in a cell-free system". The Kobe Journal of Medical Sciences. 45 (3–4): 181–90. PMID 10752311.
- Deeg MA, Bierman EL, Cheung MC (March 2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". Journal of Lipid Research. 42 (3): 442–51. PMID 11254757.
- Tang J, Li W (2002). "[Methodological study on the assay of glycosylphosphatidylinositol-specific phospholipase D activity in serum]". Hunan Yi Ke da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University. 24 (2): 119–22. PMID 11938765.
- Slomiany A, Nishikawa H, Slomiany BL (March 2002). "Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa". Journal of Physiology and Pharmacology. 53 (1): 21–38. PMID 11939716.
- Jaworek J, Bonio J, Leja-Szpa A, Nawrot K, Tomaszewska MR, Stachura J, et al. (March 2002). "Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin". Journal of Physiology and Pharmacology. 53 (1): 51–74. PMID 11939719.
- Deeg MA, Bowen RF (2002). "Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D". Biochemistry and Cell Biology. 80 (2): 253–60. PMID 11989719.
- Xiaotong H, Hannocks MJ, Hampson I, Brunner G (2002). "GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy". Clinical & Experimental Metastasis. 19 (4): 291–9. S2CID 2868010.
- Magnusson P, Sharp CA, Farley JR (November 2002). "Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts". Clinica Chimica Acta; International Journal of Clinical Chemistry. 325 (1–2): 59–70. PMID 12367767.
- Tang JH, Gu SL, Zhang XJ (April 2001). "[Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D]". Hunan Yi Ke da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University. 26 (2): 95–7. PMID 12536633.
- Kurtz TA, Fineberg NS, Considine RV, Deeg MA (February 2004). "Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D". Metabolism. 53 (2): 138–9. PMID 14767861.
- Lugli EB, Pouliot M, Portela M, Loomis MR, Raper J (November 2004). "Characterization of primate trypanosome lytic factors". Molecular and Biochemical Parasitology. 138 (1): 9–20. PMID 15500911.
- Everett PB, Senogles SE (November 2004). "D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway". Neuroscience Letters. 371 (1): 34–9. S2CID 27173449.
- Mead KI, Zheng Y, Manzotti CN, Perry LC, Liu MK, Burke F, et al. (April 2005). "Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells". Journal of Immunology. 174 (8): 4803–11. PMID 15814706.
 | This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |