GUCA1B
| GUCA1B | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 6: 42.18 – 42.19 Mb | Chr 17: 47.7 – 47.7 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene.[5][6] Alternative names:[7]
- Guanylate cyclase activator 1B
- p24
Biological Role
Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation.[8] Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase.[8] This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112599 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023979 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9119368.
- ^ "Entrez Gene: GUCA1B guanylate cyclase activator 1B (retina)".
- ^ "GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene & protein". www.uniprot.org. Retrieved 2017-10-09.
- ^ PMID 7909609.
Further reading
- Wiegand RC, Kato J, Huang MD, Fok KF, Kachur JF, Currie MG (October 1992). "Human guanylin: cDNA isolation, structure, and activity". FEBS Letters. 311 (2): 150–4. S2CID 39983596.
- de Sauvage FJ, Keshav S, Kuang WJ, Gillett N, Henzel W, Goeddel DV (October 1992). "Precursor structure, expression, and tissue distribution of human guanylin". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9089–93. PMID 1409606.
- Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczyłko J, Surgucheva I, et al. (April 1997). "Localization of guanylate cyclase-activating protein 2 in mammalian retinas". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4727–32. PMID 9114059.
- Laura RP, Hurley JB (August 1998). "The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2". Biochemistry. 37 (32): 11264–71. PMID 9698373.
- Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K (February 1999). "Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1". Biochemistry. 38 (5): 1387–93. PMID 9931003.
- Payne AM, Downes SM, Bessant DA, Plant C, Moore T, Bird AC, Bhattacharya SS (September 1999). "Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies". Journal of Medical Genetics. 36 (9): 691–3. PMID 10507726.
- Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, et al. (June 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision. 8: 196–204. PMID 12107411.
- Sato M, Nakazawa M, Usui T, Tanimoto N, Abe H, Ohguro H (March 2005). "Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 243 (3): 235–42. S2CID 23347858.
External links
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