Gastrectomy

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Gastrectomy
Diagram of the stomach, showing the different regions.
ICD-9-CM43.5-43.9
MeSHD005743
MedlinePlus002945

A gastrectomy is a partial or total surgical removal of the stomach.

Indications

Gastrectomies are performed to treat stomach cancer and perforations of the stomach wall.

In severe

gastric dumping syndrome
.

Polya's operation

Also known as the Reichel–Polya operation, this is a type of posterior gastroenterostomy which is a modification of the Billroth II operation[1] developed by Eugen Pólya and Friedrich Paul Reichel. It involves a resection of 2/3 of the stomach with blind closure of the duodenal stump and a retrocolic gastro-jejunal anastomosis.

Post-operative effects

The most obvious effect of the removal of the stomach is the loss of a storage place for food while it is being digested. Since only a small amount of food can be allowed into the small intestine at a time, the patient will have to eat small amounts of food regularly in order to prevent

gastric dumping syndrome
.

Another major effect is the loss of the

pernicious anaemia) which severely reduces red-blood cell synthesis (known as erythropoiesis, as well as other haematological cell lineages if severe enough but the red cell is the first to be affected). This can be treated by giving the patient direct injections of vitamin B12. Iron-deficiency anemia can occur as the stomach normally converts iron into its absorbable form.[2]

Another side effect is the loss of ghrelin production, which has been shown to be compensated after a while.[3] Lastly, this procedure is post-operatively associated with decreased bone density and higher incidence of bone fractures. This may be due to the importance of gastric acid in calcium absorption.[4]

Post-operatively, up to 70% of patients undergoing total gastrectomy develop complications such as dumping syndrome and reflux esophagitis.[5] A meta-analysis of 25 studies found that construction of a "pouch", which serves as a "stomach substitute", reduced the incidence of dumping syndrome and reflux esophagitis by 73% and 63% respectively, and led to improvements in quality-of-life, nutritional outcomes, and body mass index.[5]

After Bilroth II surgery, a small amount of residual gastric tissue may remain in the duodenum. The alkaline environment causes the retained gastric tissue to produce acid, which may result in ulcers in a rare complication known as retained antrum syndrome.

All patients lose weight after gastrectomy, although the extent of weight loss is dependent on the extent of surgery (total gastrectomy vs partial gastrectomy) and the pre-operative BMI. Maximum weight loss occurs by 12 months and many patients regain weight afterwards.[6]

History

The first successful gastrectomy was performed by Theodor Billroth in 1881 for cancer of the stomach.

Historically, gastrectomies were used to treat

peptic ulcers.[7] These are now usually treated with antibiotics, as it was recognized that they are usually due to Helicobacter pylori
infection or chemical imbalances in the gastric juices.

In the past a gastrectomy for peptic ulcer disease was often accompanied by a

proton pump inhibitors
.

See also

References

  1. ^ Lahey Clinic (1941). Surgical Practice of the Lahey Clinic, Boston, Massachusetts. W.B. Saunders company. p. 217. Retrieved 2008-07-18.
  2. ^ "After Stomach Cancer Surgery - Complications : Diet". Archived from the original on 2017-10-09. Retrieved 2016-01-23.
  3. PMID 15788704. Archived from the original
    (PDF) on 2016-12-25. Retrieved 2016-12-25.
  4. .
  5. ^ .
  6. .
  7. ^ E. Pólya:Zur Stumpfversorgung nach Magenresektion. Zentralblatt für Chirurgie, Leipzig, 1911, 38: 892-894.

External links