George Billman

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George Edward Billman
Born (1954-07-23) 23 July 1954 (age 69)
Fort Worth, Texas
CitizenshipAmerican
Alma materXavier University
University of Kentucky
Known forStudying the effects of exercise training and omega-3 fatty acids on the cardiovascular system
SpouseRosemary (1975–)
Children2
AwardsFellow – American Heart Association (2001)
Fellow – Heart Rhythm Society (2011)
Scientific career
FieldsPhysiology
InstitutionsUniversity of Oklahoma
Ohio State University
Thesis The Neural Control of the Coronary Circulation during Behavioral Stress in Conscious Dogs  (1980[1])
Doctoral advisorDavid C. Randall

George Edward Billman (born July 23, 1954) is an American

physiologist and professor at Ohio State University. After receiving a Ph.D from the University of Kentucky in 1980, Billman began his professional career at the University of Oklahoma
. In 1984, he joined the Ohio State staff, where he became an associate professor in 1990 and a full professor in 1996.

Billman's research has focused on

sudden cardiac death (SCD). These techniques have subsequently been used in human patients to identify people at high risk for VF. Billman has used his sudden cardiac death models to study the effects of exercise training on susceptibility to SCD and the effects of omega-3 fatty acids, among other things. Due to his use of live animals in experiments, Billman has been criticized by animal rights
activists; however, a 2009 regulatory investigation found no evidence of wrongdoing.

Early life and education

George Edward Billman was born on July 23, 1954, in

Ph.D. in physiology and biophysics in 1980.[1] From 1980–1982, Billman was a research associate under H. Lowell Stone at the University of Oklahoma.[1][2]

Career

In 1982, Billman was promoted to Assistant Professor of Research at Oklahoma. In 1984, he accepted an assistant professor position at Ohio State University. He was promoted to associate professor in 1990 and made a full professor in 1996. Billman was elected a Fellow of the American Heart Association in 2001.[2] In 2011, he was elected a Fellow of the Heart Rhythm Society.[1][3] He is also a member of The Physiological Society in London, the American Physiological Society, the International Society for the Study of Fatty Acids and Lipids (ISSFAL), and Sigma Xi.[1]

Billman has served on the editorial boards of the

Frontiers in Physiology, a position he continues to hold as of 2014.[1][4]

Billman consulted for

Sanofi Aventis since 1999.[2]

Research

Billman's research has focused on

myocytes.[1]

Model of sudden cardiac death

Billman developed a technique of inducing fatal ventricular fibrillation in dogs in the lab of H. Lowell Stone starting in 1980, and used and refined it over the next 25 years.[8][9] The model subsequently has been described as "an elegant in vivo model of sudden cardiac death" by cardiologist Michel de Lorgeril et al.[10]: 228  and "a highly reliable canine model of sudden cardiac death" by physiologist Alexander Leaf et al.[11]: 130  The model is described in Springer's handbook of reliable procedures for testing the potential effects of new drug candidates in the antiarrhythmic section.[8]

In the procedure, the left main anterior

defibrillated, allowing for repeated study of the same animals. Over time, initial results (fibrillation or no fibrillation) have proven to be 92% reproducible, allowing for precise testing of potential antiarrhythmic agents.[6]

This model of sudden cardiac death has "yielded important insights" into

ischaemic heart disease.[13] The initial study using the technique, published in 1982, found that decreased baroreflex sensitivity was associated with increased risk for ventricular fibrillation. This marked the first time an autonomic response was seen as having prognostic value. The same association was demonstrated in humans by Kleiger et al. in 1987 and "definitively" demonstrated in dogs in 1988 by Schwartz, Billman, et al.[6] On the basis of these findings, a large clinical study (Autonomic Tone and Reflexes After MI), was conducted. The 1,284 patient study "fully confirmed" baroreflex sensitivity as a valid predictor of sudden and non-sudden death after myocardial infarction (MI).[6]

Billman's model of SCD has also shown that sudden death is not a direct function of the degree of a myocardial infarction and that baroreflex gain declines during MI. Resistant dogs show a reduced heart rate during ischemia, while susceptible dogs show increased heart rate (beyond that induced by the exercise). Reviewing the findings, physiologist Dwain L. Eckberg wrote that the model "seems to be extremely relevant" to human patients at risk for sudden cardiac death.[13]

Cocaine and heart function

According to a 1990 review article by Billman, cocaine has two primary circulatory effects – increased sympathetic stimulation and cardiac ion channel inhibition – that lead to a variety of heart problems. The drug also causes increased heart rate and blood pressure. In a 1995 review article, he said resulting secondary effects include arrhythmia, coronary vasospasm, myocardial infarction, and ventricular fibrillation.[14]

Omega-3 fatty acids

Diagram showing the interaction between omega-3 fatty acids and the cardiac cell membrane (top) with the possible effect on ventricular arrhythmia (bottom).

In 1994, Billman used his model of SCD to test the ability of omega-3 polyunsaturated fatty acids to prevent fatal arrhythmias. In the test, eight dogs otherwise susceptible to ventricular fibrillation were given a direct infusion of fish oil. Seven of the eight did not have VF during the test. Five of five animals re-tested in a follow-up control test (i.e. without treatment) had VF. The observed effect most likely resulted from a combination of direct chemical interaction on the cardiac cell membrane and a reduced heart rate caused by the omega-3s.[15][16] The study was picked up by a nationally syndicated columnist, and thus reported in various popular media outlets.[16] Follow-up studies in 1997 and 1999 confirmed the results (P<0.005) and found both eicosapentaenoic acid and docosahexaenoic acid (found in fish oil), as well as α-Linolenic acid (found in vegetable oil) to have antiarrhythmic effects.[17][18][19]

The same effect has been shown to occur in humans by other researchers. Billman's more recent work has focused on discovering the biochemical mechanisms of the antiarrhythmic effects omega-3 fatty acids, and on whether the same protection can be gained through dietary omega-3 fatty acids.

phospholipids and are then released during ischemia, suggesting a possible mechanism whereby the cardiac muscle is more resistant to entering arrhythmia under stress.[10] However, large-scale clinical trials of dietary omega-3s have been inconclusive, with some studies finding significant reduction in sudden cardiac death and others finding no effect. Meta-analysis performed in 2014, found statistically significant reduction in sudden cardiac death (odds ratio (OR) 0.86; confidence interval (CI) 0.76 to 0.98), while 2013 meta-analysis using a different data set found a non-statistically significant reduction (OR 0.82; CI 0.60 to 1.21).[21][22]

Response to research

Billman's experiments have been protested by animal rights activists.

U.S. Department of Agriculture and the NIH's Office of Laboratory Animal Welfare. They alleged he was conducting redundant experiments and using unnecessarily cruel techniques.[24] Ohio State said PETA's claims "grossly misrepresented and severely discounted the scientific merit and potential public health benefit of this work."[20] Two federal investigations found no evidence of wrongdoing,[25] but PETA continued to campaign against the experiments.[25][26] In 2010, Ohio State issued an open letter in response to continued protest letters. In the statement, OSU said PETA was misleading the public by saying Billman's research was investigating the "obvious" fact that "exercise strengthens the heart" when the research was actually attempting to understand the biochemical and cellular mechanisms which lead to sudden cardiac death.[26]

Billman received a new investigator award from National Institutes of Health (

Hoffmann-La Roche, Merck, and Sanofi-Aventis.[2]

Personal life

George Billman and his wife, Rosemary, have been married since 1975. The couple have two children – George T. and Elyse T.

genealogist,[27] and has determined that his own ancestor, Hans Theobald Billmann, who emigrated to the United States in 1752, was not in turn descended from ancestors previously identified by other amateur researchers.[28]

Publications

In 2011, Billman published a review article on heart rate variability, illustrated here by an electrocardiogram recording of canine heart beat.

Billman has authored or co-authored more than 150 scientific papers, which have been cited more than 5000 times in

John Wiley and Sons, and contributed three chapters to it. According to the publisher, the book describes the state of cardiac arrhythmia treatment, and future directions the research may take.[30] In a review of the book, Peter R. Kowey praised Billman for "[encouraging] blue sky thinking" in his contributions.[31]

Books

Selected journal articles

References

  1. ^ a b c d e f g "George E Billman biography". Frontiers Media. Retrieved November 21, 2014.
  2. ^ a b c d e f g h i j Katherine H. Nemeh, ed. (2008). "Billman, George Edward". American Men & Women of Science. Vol. 1.
  3. ^ "FHRS Member Listing". Heart Rhythm Society. Retrieved January 2, 2015.
  4. ^ "OSUToday". Ohio State University. June 17, 2010. Retrieved December 29, 2014.
  5. ^ a b "George E. Billman, PhD". Ohio State. Retrieved November 24, 2014.
  6. ^
    PMID 21127379
    .
  7. ^ Carper, Jean (October 13, 1993). "Eating Fish Oil May Help Prevent Erratic Heartbeats". Chicago Sun-Times. Archived from the original on March 29, 2015. Retrieved January 2, 2015 – via HighBeam Research.
  8. ^
    ISBN 9783540714200
    .
  9. PMID 16483666
    .
  10. ^
    ISBN 978-1-59745-330-1
    .
  11. ^
    ISBN 978-3-8055-7945-2
    .
  12. PMID 12782616
    .
  13. ^ a b c Dwain L. Eckberg (2008). "Arterial Baroreflexes in Ischaemic Heart Disease, and their role in sudden cardiac death". In Marek Malik; A. John Camm (eds.). Dynamic Electrocardiography. John Wiley & Sons.
  14. S2CID 8473278
    .
  15. PMID 8183925
    .
  16. ^ a b Jean Carper (July 14, 1994). "Fish Wards Off Erratic Heartbeats". Chicago-Sun Times. King Features Syndicate.
  17. PMID 16267249
    .
  18. PMID 11181946
    .
  19. PMID 10318669
    .
  20. ^ a b Earle Holland (April 15, 2009). "Background on Billman's Heart Studies Involving the Use of Dogs". Ohio State University.
  21. PMID 24472636
    .
  22. PMID 23714269
    .
  23. ^ a b Charlie Boss (May 12, 2007). "Research on dogs at OSU protested". The Columbus Dispatch. p. 1B. Archived from the original on March 29, 2015 – via HighBeam Research.
  24. ^ a b Richard Oviatt (April 23, 2009). "Ohio State U. abuses dogs, PETA says". The Lantern.
  25. ^ a b Charlie Boss (June 25, 2009). "Feds clear OSU researcher of dog-cruelty allegations". The Columbus Dispatch. p. 1B.
  26. ^ a b "An Open Letter from Ohio State University". Ohio State University. August 26, 2010. Retrieved December 10, 2014.
  27. ^ Alice Thomas (March 18, 2004). "OSU Lands Noted Cancer Researcher". The Columbus Dispatch. p. 1B.
  28. ^ George E. Billman (Summer 2005). "The Dewalt Billmann Dilemma". Journal of the Berks County Genealogical Society. 25 (4).
  29. ^ "Billman, GE Citation Report", Web of Science, 5.15, Thomas Reuters, 2014
  30. ^ "Description of Novel Therapeutic Targets for Antiarrhythmic Drugs". John Wiley and Sons. Retrieved December 11, 2014.
  31. doi:10.1161/CIRCULATIONAHA.110.980037
    .
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