GyrA RNA motif
| gyrA RNA motif | |
|---|---|
 Consensus secondary structure of gyrA RNAs | |
| Identifiers | |
| Symbol | gyrA RNA |
| Rfam | RF01740 |
| Other data | |
| RNA type | Cis-regulatory element |
| Domain(s) | Pseudomonadales |
| PDB structures | PDBe |
The gyrA RNA motif is a conserved RNA structure identified by bioinformatics.[1] The RNAs are present in multiple species of bacteria within the order Pseudomonadales. This order contains the genus Pseudomonas, which includes the opportunistic human pathogen Pseudomonas aeruginosa and Pseudomonas syringae, a plant pathogen.
gyrA RNAs are always found in the presumed
5' untranslated regions of gyrA genes, which encodes a protein forming a subunit of a DNA gyrase. Resistance to the antibiotic ciprofloxacin in Pseudomonas is often achieved via mutations in the gyrA gene.[2] Because of its positioning, the gyrA RNA motif was hypothesized to be a cis-regulatory element acting up the downstream gyrA genes. However, gyrA was previously regarded as a gene whose level of expression is consistent in a wide variety of growth conditions.[3]
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