HLA-DQ9
MHC Class II, DQ cell surface antigen | |||||||||||||||||
| |||||||||||||||||
HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. DQ9 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.
Serology
| DQ9 | DQ3 | DQ2 | DQ7 | DQ8 | sample | |
| % | % | % | % | % | (N) | |
| *0303 | 67 | 12 | 11 | 1 | 1 | 2563 |
| Red indicates the level of 'false' reaction in non-DQ9 serotypes | ||||||
| Alleles link-out to IMGT/HLA Databease at EBI | ||||||
The serotyping efficiency of DQ9 is poor. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB1*0303 as efficiently as DQ3. For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.
DQB1*0303
(DQ9) is associated with nasal polyps,[2] gestational diabetes,[3] microscopic polyangiitis (Japanese). Primary linkage is with DRB1*0901-DQB1*0303 [4]
Haplotypes and disease
DQ9.2
DQA1*0201:DQB1*0303 is associated with type I psoriasis (vulgaris),[5][6]
DQ9.3
DQA1*0302:DQB1*0303 maybe associated with juvenile diabetes in the orient.[7][8] (Chinese) Primary linkage of vitiligo is with DQA1*03-DQB1*0303.[9]