HLA-DR3

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR3
Haplotypes groups DRA*01:DRB1*03:01 DRA*01:DRB1*03:02 DRA*01:DRB1*03:03 DRA*01:DRB1*03:04
Structure (See HLA-DR)
Identifiers
alpha *01:01
Symbol(s) HLA-DRA[permanent dead link]
EBI-HLA DRA*01:01
Identifiers
beta 1 *03:01 *03:01 *03:02 *03:03 *03:04
Symbol(s) HLA-DRB1[permanent dead link]
EBI-HLA DRB1*03:01
EBI-HLA DRB1*03:02
EBI-HLA DRB1*03:03
EBI-HLA DRB1*03:04
EBI-HLA DRB1*03:05 Archived 2007-09-26 at the Wayback Machine
Shared data
Locus
chr.6 6p21.31

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4 (only 1–3% have both), yet only a small percentage (about 0.5%) of these individuals will develop type 1 diabetes.

Serology

DR17 and DR3 recognition of some DRB1*03 alleles[1]
DRB1* DR3 DR17 DR18 Sample
allele % % % size (N)
03:01 33 64 0 9698
03:02 24 3 66 317
03:03 40 60 5
03:04 60 20 5
03:07 >50 1

Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*03:04 primarily reacts with DR3. The serotypes of *03:05, *03:06, *03:08 to *03:31 are unknown.

Disease associations

Further information: HLA A1-B8-DR3-DQ2 § Importance to Medicine

By serotype

HLA-DR3 is associated with early-age onset

AIDS,[3] but lowered risk for cancers.[4] It is also associated with membranous glomerulonephritis[5]

By allele

DRB1*03:01 (see HLA-DR17)

DRB1*03:02 (See HLA-DR18)

DRB1*03:04 is associated with

Graves disease[6]

By haplotypes

DR3 and/or DQ2 is associated with Moreen's ulceration,

systemic lupus erythematosus[10]

Diabetes mellitus type 1. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*05:01 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however in older studies DQA1*05:05 is commonly confused with DQA1*05:01)
[11]

Genetic linkage

DR3 is genetically linked to HLA-DR52, DRB3*02:02 allele, and HLA-DQ2 (DQ2.5).

References

  1. ^ derived from IMGT/HLA
  2. PMID 17257319
    .
  3. PMID 6333416
    .
  4. PMID 2395088
    .
  5. ISBN 978-0-7234-3553-2
    .
  6. S2CID 6376169
    .
  7. PMID 10611103
    .
  8. S2CID 11416838
    .
  9. PMID 8096501
    .
  10. S2CID 26486050
    .
  11. PMID 10777105
    .
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