HLA-DR15
| |
major histocompatibility complex, class II, DR15
| |
| Haplotypes groups | DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1501 to *1505 *1507
|
| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*1501 |
| EBI-HLA | DRB1*1502 |
| EBI-HLA | DRB1*1503 |
| EBI-HLA | DRB1*1504 |
| EBI-HLA | DRB1*1505 |
| EBI-HLA | DRB1*1507 |
| Shared data | |
| Locus | chr.6 6p21.31
|
HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.
Serology
| DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 1501 | 76 | 23 | 6428 | |
| 1502 | 77 | 16 | 676 | |
| 1503 | 81 | 13 | 286 | |
| 1504 | >50 | 1 | ||
| 1505 | >25 | 2 | ||
| 1507 | >50 | 1 |
Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.
Alleles
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Disease associations
DR15 is positively associated
and a predisposition for postmenopausal osteoporosis.[8]DRB1*1501 is positively associated with
DRB1*1502 is associated with
DRB1*1503 is associated with
Extended linkage
DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[21]
DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with
Genetic linkage
DR15 Haplotypes
| |||
| Serotypes | DRA | DRB1 | DRB5 |
|---|---|---|---|
| DR15(2)-DR51 | *0101 | *1501 | *0101 |
| *0101 | *1502 | *0101 | |
| *0101 | *1503 | *0101 | |
| *0101 | *1504 | *0101 | |
| *0101 | *1505 | *0101 | |
| *0101 | *1507 | *0101 | |
| DQA1 | DQB1 | DRB1 | |
| DR15(2)-DQ6(6.2, 1) | *0102 | *0602 | *1501 |
| DR15(2)-DQ6(6.1, 1) | *0103 | *0601 | *1502 |
| HLA-A | HLA-B | DRB1 | |
| A3-Cw7-B7-DR15(2) | *0301 | *0702 | *1501 |
| A1-B51-DR15(2) | *0101 | *5101 | *1502 |
HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.
References
- ^ derived from IMGT/HLA
- PMID 10917888.
- S2CID 9624250.
- PMID 6783164.
- S2CID 37606199.
- PMID 17207713.
- PMID 14592217.
- PMID 17498269.
- PMID 16105036.
- PMID 10571772.
- PMID 15120191.
- ^ PMID 15709450.
- ^ PMID 12694585.
- S2CID 10012283.
- S2CID 24141516.
- PMID 15022331.
- PMID 25634309.
- ^ PMID 12028537.
- PMID 10088769.
- S2CID 41178678.
- ^ PMID 11097225.