Hans Westerhoff

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Hans Westerhoff
Hans Westerhoff in 2014
Born
Hans Victor Westerhoff

(1953-01-14) 14 January 1953 (age 71)[2]
Amsterdam, The Netherlands
Alma materUniversity of Amsterdam (PhD)
Scientific career
FieldsBiological thermodynamics, Systems biology[1]
Institutions
ThesisMosaic non-equilibrium thermodynamics and (the control of) biological free-energy transduction (1983)
Doctoral advisorKarel van Dam[2][3]
Websitewww.manchester.ac.uk/research/hans.westerhoff

Hans Victor Westerhoff (born 14 January 1953 in

Manchester Centre for Integrative Systems Biology.[5][6]

Career

Westerhoff was educated at the University of Amsterdam where he was awarded a PhD in 1983 for investigations of non-equilibrium thermodynamics and the control of biological thermodynamics supervised by Karel van Dam.[2] In 1996 he succeeded Ad Stouthamer as professor of microbiology at the Vrije Universiteit Amsterdam.[7]

Research

At the beginning of his career Westerhoff worked in the area of non-equilibrium thermodynamics in relation to biological energy transduction.[8][9] His work on this topic led to a book written with Karel Van Dam.[10]

After being a coauthor of one of the first experimental papers to stimulate interest in metabolic control analysis[11] and participating in the group that proposed a harmonized terminology,[12] Westerhoff moved progressively towards working on multi-enzyme systems as his major activity, starting with an analysis of the effect of enzyme activity on metabolite concentrations.[13] He published many papers in this area, of which one may note an analysis of the control of regulatory cascades,[14] analysqis of glycolytic oscilations in yeast,[15] and showing that the in vivo behaviour of Trypanosoma brucei agreed with the kinetic properties of the glycolytic enzymes.[16]

Westerhoff and colleagues discovered magainin in the African clawed frog which helps it fight against bacteria.[17] In December 1996 he and his group discovered a nitric-oxide reductase of Paracoccus denitrificans.[18]

In conjunction with many other workers Westerhoff used a community approach to construct a consensus yeast metabolic network[19] and subsequently applied the same approach to human metabolism.[20]

References

  1. ^ a b "Hans Westerhoff". Google Scholar. Archived from the original on December 18, 2013. Retrieved December 9, 2013.
  2. ^ a b c d Prof. dr. H.V. Westerhoff, 1953- at the University of Amsterdam Album Academicum website
  3. ^ Academic Tree: Karel van Dam, Amsterdam
  4. ^ "Prof. Dr. H.V. (Hans) Westerhoff". University of Amsterdam. Archived from the original on December 12, 2013. Retrieved December 9, 2013.
  5. ^ "Professor Hans Westerhoff". University of Manchester. Archived from the original on December 15, 2013. Retrieved December 9, 2013.
  6. ^ Hans Westerhoff's publications indexed by the Scopus bibliographic database. (subscription required)
  7. ^ Martine Zuidweg (11 June 1997). "De confrontatie" (in Dutch). Trouw. Retrieved 19 July 2020.
  8. PMID 7397133
    .
  9. PMID 6267598
    .
  10. ISBN 978-0-444-80783-0
    .
  11. PMID 7061448
    .
  12. doi:10.1016/0968-0004(85)90008-8
    .
  13. PMID 6745283
    .
  14. PMID 1686290
    .
  15. PMID 10692299
    .
  16. PMID 9013556
    .
  17. PMID 7705337
    .
  18. PMID 9022686
    .
  19. PMID 18846089
    .
  20. PMID 23455439
    .
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