Hegedus indole synthesis

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Hegedus indole synthesis
Named after Louis S. Hegedus
Reaction type Ring forming reaction

The Hegedus indole synthesis is a

indoles through palladium(II)-mediated oxidative cyclization of ortho-alkenyl anilines.[1][2][3][4][5][6] The reaction can still take place for tosyl-protected amines.[4]

Application

2-Allylaniline can be converted to 2-Methylindole using the Hegedus indole synthesis.[1]

References

  1. ^
    doi:10.1021/ja00425a051
    .
  2. doi:10.1021/ja00486a035
    .
  3. doi:10.1021/jo00324a004
    .
  4. ^
    doi:10.1021/jo00189a001
    .
  5. ISBN 9780470638859
    .
  6. ISBN 978-3-540-30030-4
    .


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