Heptamethine dyes

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Heptamethine dyes are a subclass of chemical compounds within the

fluorescent dyes, particularly in biomedical imaging, the development of theranostics, the individualized treatment of cancerous patients with the aid of PDT, co-administration with other drugs, and irradiation.[1][2]

The characteristics of heptamethine dyes can be understood by comparing research data on different dyes within the family. For example, the IR-780 dye exhibits a peak spectral absorption of around 780 nm.[3]

Optical properties

The absorption and fluorescence spectrum of heptamethine dyes are in the

biomedical imaging due to their significant tissue penetration and imaging signature relative to background frequencies.[5]

Patents

International patents on the use of heptamethine dyes for use in photographic use have also been approved and instituted. Fuji film placed a patent titled “Heptamethine cyanine compound, near infrared absorbing ink, near infrared absorbing sheet and silver halide photographic material” in 1999 and a follow-up international patent 6072059 in 2000.

Heptamethine dyes for near infrared fluorescent imaging are manufactured by such companies as Intrace Medical, Lumiprobe, Cyandye, LI-COR Biosciences - GmbH and others.

References

  1. ^
    PMID 22182749
    .
  2. ^ F. Pene, E. Courtine, A. Cariou, J.P. Mira. Toward theranostics. Crit Care Med, 37 (2009), pp. S50–S58
  3. PMID 20410058
    .
  4. .
  5. ^ "Near Infrared Dyes - Cytodiagnostics".