Human platelet antigen
Human platelet antigens (HPA) are
donors with different HPAs. These antibodies cause neonatal alloimmune thrombocytopenia, post-transfusion purpura, and some cases of platelet transfusion refractoriness to infusion of donor platelets.[1]
Overview
A nomenclature was devised by International Society of Blood Transfusion (ISBT), platelet working party to overcome problems generated by many different nomenclatures in use. Since inception of this list, a greater number of antigens have been described and the molecular basis of many has been resolved.[citation needed]
To date, 24 platelet-specific alloantigens have been defined by
alloantibodies against the thetical but not the antithetical antigen have been observed. The molecular basis of 22 of the 24 serologically defined antigens has been resolved. In all but one of the 22, the difference between self and non-self is defined by a single amino acid substitution generally caused by a single-nucleotide polymorphism (SNP).[citation needed
]
| System | Antigen | Original names | Glycoprotein | CD |
|---|---|---|---|---|
| HPA-1 | HPA-1a | 1aZw | GPIIIa | CD61
|
| HPA-1b | Zwb | GPIIIa | CD |
References
- S2CID 27653273.
External links
- http://www.ebi.ac.uk/ipd/hpa/
- Human+Platelet+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This immunology article is a stub. You can help Wikipedia by expanding it. |