ITPKB
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| Location (UCSC) | Chr 1: 226.63 – 226.74 Mb | Chr 1: 180.16 – 180.25 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.[5][6]
Function
The protein encoded by the ITPKB gene is one of 3 isoforms of
IP3. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.[7] Itpkb regulates immune cell function and is required for T and B cell development.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000143772 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038855 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1654894.
- PMID 1330886.
- ^ "Entrez Gene: ITPKB inositol 1,4,5-trisphosphate 3-kinase B".
- PMID 20336153.
Further reading
- Szlufcik K, Missiaen L, Parys JB, et al. (2006). "Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences". Biol. Cell. 98 (1): 1–14. S2CID 36990427.
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