In silico clinical trials

An in silico clinical trial, also known as a virtual clinical trial, is an individualized

The term in silico indicates any use of computers in clinical trials, even if limited to management of clinical information in a database.[1]

Rationale

The traditional model for the development of medical treatments and devices begins with

• Taking account of factors such as the patient's particular physiology, the individual manifestation of the disease being treated, their lifestyle, and the presence of co-morbidities.[4]^[6]
• intention to treat
  principle.

Aim

Accurate computer models of a treatment and its deployment, as well as patient characteristics, are necessary precursors for the development of in silico clinical trials.^[5][6][8][9] In such a scenario, ‘virtual’ patients would be given a ‘virtual’ treatment, enabling observation through a computer simulation of how the candidate biomedical product performs and whether it produces the intended effect, without inducing adverse effects. Such in silico clinical trials could help to reduce, refine, and partially replace real clinical trials by:

• Reducing the size and the duration of clinical trials through better design,^[6][8] for example, by identifying characteristics to determine which patients might be at greater risk of complications or providing earlier confirmation that the product^[5] or process^[10] is working as expected.
• Refining clinical trials through clearer, more detailed information on potential outcomes and greater explanatory power in interpreting any adverse effects that might emerge, as well as better understanding of how the tested product interacts with the individual patient anatomy and predicting long-term or rare effects that clinical trials are unlikely to reveal.^[9]
• Partially replacing clinical trials in those situations where it is not an absolute regulatory necessity, but only a legal requirement. There are already examples where regulators have accepted the replacement of animal models with in silico models under appropriate conditions.^[11] While real clinical trials will remain essential in most cases, there are specific situations where a reliable predictive model can conceivably replace a routine clinical assessment.

In addition, real clinical trials may indicate that a product is unsafe or ineffective, but rarely indicate why or suggest how it might be improved. As such, a product that fails during clinical trials may simply be abandoned, even if a small modification would solve the problem. This stifles innovation, decreasing the number of truly original biomedical products presented to the market every year, and at the same time increasing the cost of development.^[12] Analysis through in silico clinical trials is expected to provide a better understanding of the mechanism that caused the product to fail in testing,^[8][13] and may be able to provide information that could be used to refine the product to such a degree that it could successfully complete clinical trials.

In silico clinical trials would also provide significant benefits over current pre-clinical practices. Unlike animal models, the virtual human models can be re-used indefinitely, providing significant cost savings. Compared to trials in animals or a small sample of humans, in silico trials might more effectively predict the behaviour of the drug or device in large-scale trials, identifying side effects that were previously difficult or impossible to detect, helping to prevent unsuitable candidates from progressing to the costly phase 3 trials.^[12]

In radiology

One relatively well-developed field of in-silico clinical trials is radiology, where the entire imaging process is digitized.^[14][15] The development has accelerated in recent years following the growth of computer capacity and more advanced simulation models, and is now at the point that virtual platforms are gaining acceptance by regulatory bodies as a complement to conventional clinical trials for new product introductions.^[16]

A complete framework for in-silico clinical trials in radiology needs to include the following three components: 1) A realistic patient population, which is computer simulated using software phantoms; 2) The simulated response of the imaging system; 3) Image evaluation in a systematic way by human or model observers.^[14][15]

Computational phantoms for imaging in-silico trials require a high degree of realism because images will be produced and evaluated. To date, the most realistic whole-body phantoms are so-called boundary representation (BREP) phantoms, which are surface representations of segmented 3D patient data (MRI or CT).^[17] The fitted surfaces allow for modelling anatomical changes or motion in addition to realistic anatomy. Existing models for generating intra-organ structures are based on mathematical modelling, patient images, or generative adversarial network (GAN) modelling of patient images.^[16][18] Models of pathologies are important for simulating clinical applications targeted on specific diseases. State-of-the-art models are based on segmented lesions with enhancements for structures above the resolution limit of the imaging system using digital pathology or physiological growth models.^[19] GAN models have been used to simulate disease as well.^[20] In addition to the above, models have been developed for organ and patient motion, blood flow and contrast agent perfusion.

The response of the imaging system is generally simulated with Monte-Carlo or raytracing system models, benchmarked to measurements on physical phantoms.^[21][22] Medical imaging has a long history of system simulation for technology development and proprietary as well as public-domain models exist for a wide range of imaging systems.

The final step of an imaging in-silico trial is evaluation and interpretation of the generated images in a systematic way. The images can be evaluated by humans in ways similar to a conventional clinical trial, but for an in-silico trial to be really effective, image interpretation as well needs to be automized. For detection and quantification tasks, so-called observer models have been thoroughly studied and validated against human observers, and a range of spatial-domain models exist in the literature.^[23] Image interpretation based on deep learning and artificial intelligence (AI) is an active research field,^[24] and might become a valuable aid for the radiologist to find abnormalities or to make decisions. Applying AI observers in in-silico trials is relatively straightforward as the entire image chain is digitized.

See also

• In silico
• in silico medicine
• Virtual Physiological Human
• Virtual screening

References

 This article incorporates text available under the CC BY 4.0 license.