Indeterminate cell histiocytosis
| Indeterminate cell histiocytosis | |
|---|---|
| Other names | Indeterminate dendritic cell tumor |
| Specialty | Dermatology |
Indeterminate cell histiocytosis (LCH) is an uncommon proliferative illness where the predominant cells have characteristics from both non-Langerhans cell histiocytosis (NLCH) and Langerhans cell histiocytosis (LCH) in terms of morphology and immunophenotypic characteristics.[1] Wood et al. originally described ICH in 1985 as a neoplastic disease arising from dermal indeterminate cells that lack Birbeck granules but are characteristically positive for S-100 and CD1a.[2]
Signs and symptoms
Clinically, ICH is defined by pink to reddish, varying-sized, painless, non-itching
mucosae). These lesions can appear as a single, distinct group of lesions, or several generalized papules dispersed over the trunk, face, and limbs. They can also show signs of stable disease, remission and recurrence, or spontaneous remission.[3]
Causes
Possible causes include scabies,[4] mosquito bites,[5] and a clonal drive.[6]
Treatment
Treatment include 5%
See also
- Non-X histiocytosis
- List of cutaneous conditions
References
Further reading
- Wang, Chun-Hua; Chen, Gwo-Shing (2004). "Indeterminate Cell Histiocytosis: A Case Report". The Kaohsiung Journal of Medical Sciences. 20 (1). Wiley: 24–29. PMID 15481563.
- Zanella, Simone; Berti, Emilio; Bonometti, Arturo; for Associazione Italiana Ricerca Istiocitosi ONLUS (2023). "Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features". Journal of the European Academy of Dermatology and Venereology. 37 (8): 1559–1575. S2CID 257954148.