JWH-116

JWH-116
Legal status
Legal status	CA: Schedule II; DE: NpSG (Industrial and scientific use only); UK: Class B; US: Schedule I;
Identifiers
	IUPAC name (2-Ethyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone;
JSmol)	Interactive image;
	SMILES CCCCCN1C2=CC=CC=C2C(=C1CC)C(=O)C3=CC=CC4=CC=CC=C43;
	InChI InChI=1S/C26H27NO/c1-3-5-10-18-27-23(4-2)25(22-15-8-9-17-24(22)27)26(28)21-16-11-13-19-12-6-7-14-20(19)21/h6-9,11-17H,3-5,10,18H2,1-2H3; Key:AQHPTHKEKSWGPO-UHFFFAOYSA-N;

JWH-116 is a synthetic

naphthoylindole family. It is the indole 2-ethyl derivative of related compound JWH-018. The binding affinity of JWH-116 for the CB₁ receptor is reported as K_i = 52 ± 5 nM.^[1]

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-116 are

Schedule I Controlled Substances.^[2]

References

S2CID 29107765
.

^ 21 U.S.C. § 812: Schedules of controlled substances

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[Huffman_2003-1] S2CID 29107765
.

[2] 21 U.S.C. § 812: Schedules of controlled substances

[1]

[2]

See also

References