JWH-250

Source: Wikipedia, the free encyclopedia.
JWH-250
Legal status
Legal status
Identifiers
  • 2-(2-Methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
JSmol)
  • COc2ccccc2CC(=O)c(c3ccccc13)cn1CCCCC
  • InChI=1S/C22H25NO2/c1-3-4-9-14-23-16-19(18-11-6-7-12-20(18)23)21(24)15-17-10-5-8-13-22(17)25-2/h5-8,10-13,16H,3-4,9,14-15H2,1-2H3 ☒N
  • Key:FFLSJIQJQKDDCM-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an

CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2'-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands.[3] Other 2'-substituted analogues such as the methyl, chloro and bromo compounds are also active and somewhat more potent.[4][5]

History

JWH-250 was discovered by, and named after the researcher

(C8)-CP 47,497 and JWH-018.[6] An ELISA immunoassay technique for detecting JWH-250 in urine has been reported.[7]

Legal status

Australia

JWH-250 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).[8] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[8]

United States

In the United States, CB1 receptor agonists of the 3-phenylacetylindole class such as JWH-250 are

Schedule I Controlled Substances.[9]

See also

References

  1. ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. ^ Legal article in Latvian (www.likumi.lv)
  3. PMID 16005223
    .
  4. PMID 18473928
    .
  5. ISBN 978-1-58829-712-9
  6. ^ "Understanding the 'Spice' phenomenon. EMCDDA, Lisbon, November 2009" (PDF). Archived from the original (PDF) on 2010-04-08. Retrieved 2009-11-05.
  7. PMID 23625703
    .
  8. ^ a b Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534
  9. ^ 21 U.S.C. § 812: Schedules of controlled substances
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