Jeffery W. Kelly
Jeffery W. Kelly | |
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Born | Medina, New York, U.S. | August 23, 1960
Alma mater | |
Awards | Breakthrough Prize in Life Sciences (2022) Wolf Prize (2023) |
Scientific career | |
Institutions |
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Jeffery W. Kelly (born August 23, 1960 in
Biography
Kelly received his Ph.D. in organic chemistry from the University of North Carolina at Chapel Hill (1986) and performed post-doctoral research at The Rockefeller University (1986–89).[1]
He is former Dean of Graduate Studies (2000–2008) and Vice President of Academic Affairs (2000–2006) and co-Chairman of Molecular Medicine and the Lita Annenberg Hazen Professor of Chemistry within the Skaggs Institute of Chemical Biology at The
Kelly has cofounded three biotechnology companies, FoldRx Pharmaceuticals with
His lab began looking for ways to inhibit
Honors and awards
1991 -
1999 - Biophysical Society National Lecturer (Award)
1999 - Protein Society-Dupont Young Investigator Award
2000 - SUNY at Fredonia Alumni Distinguished Achievement Award
2001 - American Chemical Society Arthur C. Cope Scholar Award
2006 - National Institutes of Health Merit Award
2008 - American Peptide Society Vincent du Vigneaud Award
2011 - American Peptide Society Rao Makineni Lectureship (Award)
2011 - Protein Society Emil T. Kaiser Award
2012 - American Chemical Society, Ralph F. Hirschmann Award in Peptide Chemistry
2012 - the Biopolymers Murray Goodman Memorial Prize
2016 - Royal Society of Chemistry Jeremy Knowles Award
2016 - Jacob Heskel Gabbay Award in Biotechnology and Medicine
2016 - Commencement address at SUNY Fredonia.[9]
2016 - Member of the American Academy of Arts and Sciences
2017 - Chemical Pioneer Award of the American Institute of Chemists
2017 - Fellow of the Royal Society of Chemistry
2017 - Fellow of the National Academy of Inventors
2022 - Breakthrough Prize in Life Sciences
2023 - Wolf Prize in Chemistry[10]
Significant Papers
1992 Colon, W.; Kelly, J.W. "Partial Denaturation of Transthyretin is Sufficient for Amyloid Fibril Formation In Vitro." Biochemistry, 31 8654-8660.
2001 Jager, M.; Nguyen, H.; Crane, J.C.; Kelly, J.W.; Gruebele, M. "The Folding Mechanism of a β-Sheet: The WW Domain" J. Mol. Biol., 311, 373-393.
2001 Hammarstrom, P.; Schneider, F.; Kelly, J.W. "Trans-Suppression of Misfolding In An Amyloid Disease" Science 293, 2459-2461.
2002 Sawkar, A.R.; Cheng, W-C.; Beutler, E.: Wong, C.–H.: Balch, W.E.: Kelly, J.W. "Chemical Chaperones Increase the Cellular Activity of N370S β-glucosidase: A Therapeutic Strategy for Gaucher Disease " Proc. Natl. Acad. Sci. 99, 15428-15433.
2003 Hammarstrom, P.; Wiseman, R. L.; Powers, E.T.; Kelly, J.W. "Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics" Science 299, 713-716.
2004 Deechongkit, S.; Nguyen, H.; Dawson, P.E.; Gruebele, M.; Kelly, J.W. “Context Dependent Contributions of Backbone H-Bonding to β-Sheet Folding Energetics” Nature 430, 101-105.
2005 Sekijima, Y., Wiseman, R.L., Matteson, J., Hammarström, P., Miller,S.R., Balch, W.E., Kelly, J.W. “Biological and Chemical Basis for Tissue Selective Amyloid Disease”Cell 121, 73-85.
2006 Fowler, D.M.; Koulov, A.V.; Alory-Jost, C.; Marks, M.S.; Balch, W.E; Kelly, J.W. "Functional Amyloid Formation Within Mammalian Tissue " PLoS Biology 4, 100-107.
2008 Mu, T-W.; Ong, D.S.T.; Wang, Y-J; Balch, W. E.; Yates, J.R.; Segatori, L.; Kelly, J.W. .”Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases” Cell 134, 769-781.
2008 Balch, W.E.; Morimoto, R.I.; Dillin, A.; Kelly, J.W. “Adapting Proteostasis For Disease Intervention” Science 319, 916-919.
2010 Wiley; died in a car crash
2011 Culyba, E.K.; Price, J.L.; Hanson, S.R.; Dhar, A,; Wong, C-H.; Gruebele, M.; Powers, E.T.; Kelly, J.W. “Protein Native State Stabilization by Placing Aromatic Side Chains in N-Glycosylated Reverse Turns” Science 331, 571-575.
2012 Bulawa, C.E.; Connelly, S.; DeVit, M.; Wang, L. Weigel, C.;Fleming, J. Packman, J.; Powers, E.T.; Wiseman, R.L.; Foss, T.R.; Wilson, I.A.; Kelly, J.W.; Labaudiniere, R. “Tafamidis, A Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade” Proc. Natl. Acad. Sci. 109, 9629-9634.
2013 Chen, W; Enck, S.; Price, J.L.; Powers, D.L.; Powers, E.T.; Wong, C-H.; Dyson, H.J.; Kelly, J.W. “The Structural and Energetic Basis of Protein-Carbohydrate Interactions” J. Am. Chem. Soc. 135, 9877-9884.
References
- ^ a b c Faculty biography, Scripps, Retrieved April 2, 2018
- ^ .
- ^ Timmerman, Luke (May 3, 2010). "Proteostasis, with San Diego Roots and Boston Home, Seeks Edge in Alzheimer's and Parkinson's". Xconomy.
- ^ "Form S-1". Proteostasis Therapeutics via SEC Edgar. December 23, 2015.
- ^ Preston, Juliet (February 5, 2013). "J&J Creates Space at Janssen Labs for Life Sciences Entrepreneurs". Xconomy.
- ISBN 978-1-84973-806-4.
- ^ doi:10.1038/nrd3316.
- .
- ^ see Commencement address at: youtu.be/4YA7btif6A8
- ^ Wolf Prize in Chemistry 2023