Jesse D. Bloom

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Jesse D. Bloom is an American computational

Fred Hutchinson Cancer Center.[1] He is also an Investigator of the Howard Hughes Medical Institute, and an Affiliate Professor in the University of Washington departments of Genome Sciences and Microbiology.[2][3][4]

Education and career

Bloom obtained a B.S. in

Fred Hutchinson Cancer Center in 2011 and an Investigator of the Howard Hughes Medical Institute in 2018.[6][7]

Research

Bloom’s research focuses on the molecular evolution of viruses and viral proteins, particularly of rapidly-evolving RNA viruses like influenza, HIV, and SARS-CoV-2.[1][8][9][10] His lab uses a combination of computational and experimental techniques to understand how changes in viral proteins result in immune escape, drug resistance, and shifts in host specificity.[2] His group performed the first experimental study showing that human coronaviruses evolve to escape from human antibodies.[11]

Bloom has helped lead the development of deep mutational scanning techniques for measuring the effects of large numbers of mutations in viral proteins in parallel.

antibodies and naturally elicited immune responses.[13][14] His group has integrated these measurements into an antibody-escape calculator that is used to help track SARS-CoV-2 evolution.[15] They also showed that the ability to bind human ACE2 is widespread and highly evolvable among natural SARS-related coronaviruses, highlighting the zoonotic potential of this family of viruses.[16]

Bloom's scientific work has been published in top scientific journals including Science, Nature, and Cell.[13][17][10][16]

In addition to his scientific publications, Bloom has authored several columns with Sarah Cobey in the New York Times about SARS-CoV-2 evolution.[18][19]

Bloom has also argued that it is important for virologists to ensure that virology research is performed responsibly and does not create biosafety or biosecurity risks. He outlined his views in a column he published on the topic in the New York Times.[20]

In 2021, Bloom was a co-author of a letter calling for further investigation of COVID-19 origins published in Science.[21] Bloom's research on the origin of COVID-19 "raised the possibility that the Chinese government might be trying to hide evidence about the pandemic’s early spread" and was the subject of a meeting with Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases (NIAID).[22][23]

Honors and awards

  • 2019 McDougall Mentoring Award[24]
  • 2018 HHMI Investigator[25]
  • 2017 Merck Irving S. Sigal Award from the American Society for Microbiology [26]
  • 2016 Ann Palmenberg Junior Investigator Award from the American Society for Virology[27]
  • 2016 HHMI-Simons Faculty Scholar[28]
  • 2015 Young Investigator in Virology Award[29]
  • 2015 Pew Scholar in Biomedical Sciences[30]
  • 2012 Searle Scholar Award[31]

External links

References

  1. ^ a b c "Jesse Bloom, Ph.D." Fred Hutch. Retrieved 2022-05-18.
  2. ^ a b "Jesse D. Bloom". HHMI. Retrieved 2022-10-29.
  3. ^ "Jesse D. Bloom | UW Microbiology". microbiology.washington.edu. Retrieved 2022-10-29.
  4. ^ "UW Genome Sciences: Jesse Bloom". www.gs.washington.edu. Retrieved 2022-10-29.
  5. ^ "Jesse Bloom". www.aiche.org. 2021-03-05. Retrieved 2022-10-29.
  6. ^ "Jesse Bloom, Ph.D." Fred Hutch. Retrieved 2022-12-17.
  7. ^ "Jesse D. Bloom". HHMI. Retrieved 2022-12-17.
  8. ^
    PMID 25006036
    .
  9. PMID 27959955
    .
  10. ^
    PMID 32841599
    .
  11. PMID 33831132
    .
  12. bioRxiv 10.1101/2022.10.13.512056
    .
  13. ^
    PMID 33495308
    .
  14. PMID 33592168
    .
  15. PMID 35573973
    .
  16. ^
    PMID 35114688
    .
  17. S2CID 235907733
    .
  18. ISSN 0362-4331
    . Retrieved 2022-12-17.
  19. ISSN 0362-4331
    . Retrieved 2022-12-17.
  20. ISSN 0362-4331
    . Retrieved 2022-12-17.
  21. PMID 33986172
    .
  22. ^ ""This Shouldn't Happen": Inside the Virus-Hunting Nonprofit at the Center of the Lab-Leak Controversy". Vanity Fair. 2022-03-31. Retrieved 2022-05-18.
  23. PMID 34398234
    .
  24. ^ "McDougall Mentoring Award" (PDF). Jan 6, 2022.
  25. ^ "Jesse Bloom, PhD". HHMI. Retrieved 2022-10-29.
  26. ^ "Good News: Malik and Bloom win ASM awards; pilot project funded by Bezos family aims to create personalized anticancer vaccines". Fred Hutch. 2016-11-14. Retrieved 2022-12-17.
  27. ^ "Ann Palmenberg Junior Investigator Award". American Society for Virology. Retrieved 2022-12-17.
  28. ^ "People". Simons Foundation. Retrieved 2022-10-29.
  29. ^ Vazquez, Franck (2015-02-17). "The 2015 Viruses Young Investigator Prize Has Been Awarded!". MDPI Blog. Retrieved 2022-12-17.
  30. ^ Trusts, The Pew Charitable. "Pew Names 22 Top Scientists as Scholars in the Biomedical Sciences". www.prnewswire.com (Press release). Retrieved 2022-12-17.
  31. ^ "Scholar Profile Jesse D. Bloom". Searle Scholars Program. Archived from the original on September 5, 2015. Retrieved 2 June 2023.
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