John McCafferty
John McCafferty is a British scientist, one of the founders of
In 2002, after 12 years in Cambridge Antibody Technology (now MedImmune, a fully owned subsidiary of pharmaceutical giant AstraZeneca), McCafferty set up a group at the Sanger Institute developing and utilising methods for protein generation and recombinant antibody isolation in high throughput for proteomic applications. McCafferty has been involved in developing large human antibody repertoires both at CAT and at the Sanger Institute from which antibodies of high affinity and specificity to any antigen can be derived. He ran a laboratory at the Biochemistry Dept at University of Cambridge capitalising on the above technologies with a focus on the study of protein:protein interactions driving direct cell:cell communication[7][8][9][10][11][12] and has recently founded a new therapeutic antibody discovery biotechnology company, IONTAS Ltd.
In 2018, McCafferty's 1990 phage research paper was cited by the Nobel committee when awarding the chemistry prize to Sir Gregory Winter and George Smith.[13]
References
- S2CID 4258014.
- ^ "Dr John McCafferty on how his antibody phage display work contributed to a Nobel Prize". Next Generation Therapeutics.
- S2CID 205266758.
- ^ "Cambridge Antibody: Sales update | Company Announcements | Telegraph". Archived from the original on 2011-07-17. Retrieved 2009-07-27.
- ^ "The Top 15 Best-Selling Drugs of 2016". 6 March 2017.
- ^ "AbbVie Reports Full-Year and Fourth-Quarter 2017 Financial Results | AbbVie News Center".
- ^ "Research in the Department of Biochemistry". Archived from the original on 2009-12-08. Retrieved 2009-12-23.
- ^ http://www.repairingthebody.com/jmccafferty.html[permanent dead link]
- ^ Schofield DJ, Pope A, Clementel V, Buckell J, Chapple SDJ,, Clarke KF, Conquer JS, Crofts AM, Crowther SRE, Dyson MR, Flack G, Griffin GJ, Hooks Y, Howat WJ, Kolb-Kokocinski A,, Kunze S, Martin CD, Maslen GL,, Mitchell JM, OÕSullivan M, Perera RL, Roake W, Shadbolt SP, Vincent KJ, Warford A, Wilson WE, Xie J, Young JL, McCafferty J (2007) Application of phage display to high throughput antibody generation and characterisation. Genome Biology. 8 (11) R254
- ^ Dyson MR, Perera RL, Shadbolt SP, Biderman L, Bromek K, Murzina NV, McCafferty J (2008) Identification of soluble protein fragments by gene fragmentation and genetic selection. Nucl Acid Research 36 e51 http://nar.oxfordjournals.org/cgi/reprint/36/9/e51
- ^ Teng MS, Shadbolt P, Fraser AG, Jansen G, and McCafferty J. (2008) Control of feeding behaviour in C. elegans by human G protein coupled receptors permits screening for agonist-expressing bacteria. Proc Natl Acad Sci, 105 (39) 14826-14831
- ^ Chapple SDJ, Crofts AM, Shadbolt SP, McCafferty J, Dyson MR (2006) Multiplexed expression and screening for recombinant protein production in mammalian cells. BMC Biotechnology 6:49 http://www.biomedcentral.com/1472-6750/6/49
- ^ "Dr John McCafferty on how his antibody phage display work contributed to a Nobel Prize". Next Generation Therapeutics.