Keratin 15
| KRT15 | |||
|---|---|---|---|
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 41.51 – 41.52 Mb | Chr 11: 100.02 – 100.03 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Keratin 15 is a protein that in humans is encoded by the KRT15 gene.[5][6] It has also been referred to as cytokeratin 15, K1CO and KRTB.
Keratin 15 is a
type I cytokeratin. It is well-expressed in the basal layer of complex epithelia. However, acral keratinocytes express little to no keratin 15.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171346 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054146 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1702379.
- PMID 16831889.
- PMID 35900871.
Further reading
- Radoja N, Stojadinovic O, Waseem A, Tomic-Canic M, Milisavljevic V, Teebor S, Blumenberg M (April 2004). "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription". Molecular and Cellular Biology. 24 (8): 3168–3179. PMID 15060141.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. S2CID 4427026.
- Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ (December 2009). "Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin". Aging Cell. 8 (6): 738–751. S2CID 8832389.
- Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S, et al. (March 1999). "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes". The Journal of Investigative Dermatology. 112 (3): 362–369. PMID 10084315.
- Blumenberg M, Savtchenko ES (1986). "Linkage of human keratin genes". Cytogenetics and Cell Genetics. 42 (1–2): 65–71. PMID 2424675.
- Marchuk D, McCrohon S, Fuchs E (March 1985). "Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene". Proceedings of the National Academy of Sciences of the United States of America. 82 (6): 1609–1613. PMID 2580298.
- Bader BL, Jahn L, Franke WW (December 1988). "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene". European Journal of Cell Biology. 47 (2): 300–319. PMID 2468493.
- Choi CW, Park HS, Kim YK, Lee SH, Cho KH (August 2008). "Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma". The Journal of Dermatology. 35 (8): 499–502. S2CID 36019385.
- Romano V, Bosco P, Rocchi M, Costa G, Leube RE, Franke WW, Romeo G (1988). "Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes". Cytogenetics and Cell Genetics. 48 (3): 148–151. PMID 2466616.
- Leube RE, Bader BL, Bosch FX, Zimbelmann R, Achtstaetter T, Franke WW (April 1988). "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15". The Journal of Cell Biology. 106 (4): 1249–1261. PMID 2452170.
- Hanukoglu I, Fuchs E (November 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–252. S2CID 35796315.
- Celis JE, Gromova I, Cabezón T, Gromov P, Shen T, Timmermans-Wielenga V, et al. (December 2007). "Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease". Molecular Oncology. 1 (3): 321–349. PMID 19383306.
- Werner S, Munz B (January 2000). "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo". Experimental Cell Research. 254 (1): 80–90. PMID 10623468.
- Whittock NV, Eady RA, McGrath JA (January 2000). "Genomic organization and amplification of the human keratin 15 and keratin 19 genes". Biochemical and Biophysical Research Communications. 267 (1): 462–465. PMID 10623642.
- Al-Refu K, Goodfield M (May 2009). "Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus". Autoimmunity Reviews. 8 (6): 474–477. PMID 19162247.