Keratin 20
| KRT20 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 40.88 – 40.89 Mb | Chr 11: 99.32 – 99.33 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene.[5][6][7]
Keratin 20 is a
mucosa.[8]
In
Merkel cell carcinoma, but is absent in lung cancer, prostate cancer, and non-mucinous ovarian cancer. It is often used in combination with antibodies to CK7 to distinguish different types of glandular tumour.[9]
References
- ^ a b c ENSG00000263057 GRCh38: Ensembl release 89: ENSG00000171431, ENSG00000263057 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035775 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8359595.
- PMID 12515621.
- PMID 16831889.
- PMID 1696264.
- ISBN 1-84110-100-1.
Further reading
- Nordgírd O, Oltedal S, Kørner H, et al. (2009). "The potential of cytokeratin 20 and mucin 2 mRNA as metastasis markers in regional lymph nodes of colon cancer patients investigated by quantitative RT-PCR". Int J Colorectal Dis. 24 (3): 261–8. S2CID 10831713.
- Wong CS, Cheung MT, Ma BB, et al. (2008). "Isolated tumor cells and circulating CK20 mRNA in pN0 colorectal cancer patients". Int. J. Surg. Pathol. 16 (2): 119–26. S2CID 29407811.
- Nishigami T, Onodera M, Torii I, et al. (2009). "Comparison between mucinous cystic neoplasm and intraductal papillary mucinous neoplasm of the branch duct type of the pancreas with respect to expression of CD10 and cytokeratin 20". Pancreas. 38 (5): 558–64. S2CID 30111257.
- Saad RS, Silverman JF, Khalifa MA, Rowsell C (2009). "CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma". Appl. Immunohistochem. Mol. Morphol. 17 (3): 196–201. S2CID 37115618.
- Kim JJ, Lee HI, Park T, et al. (2010). "Identification of 15 loci influencing height in a Korean population". J. Hum. Genet. 55 (1): 27–31. PMID 19893584.
- González JJ, Bernardo CG, Sanz L, et al. (2007). "Mismatch repair protein MSH2, cytokeratin 18 and cytokeratin 20 expression: clinicopathological correlation and prognostic value in colorectal cancer patients". Hepatogastroenterology. 54 (80): 2266–71. PMID 18265645.
- Wang YD, Wu P, Mao JD, et al. (2007). "Relationship between vascular invasion and microvessel density and micrometastasis". World J. Gastroenterol. 13 (46): 6269–73. PMID 18069772.
- Chan CW, Wong NA, Liu Y, et al. (2009). "Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1". Proc. Natl. Acad. Sci. U.S.A. 106 (6): 1936–41. PMID 19188603.
- Koga T, Tokunaga E, Sumiyoshi Y, et al. (2008). "Detection of circulating gastric cancer cells in peripheral blood using real time quantitative RT-PCR". Hepatogastroenterology. 55 (84): 1131–5. PMID 18705345.
- D'Armento G, Daniele L, Mariani S, et al. (2009). "Added value of combined gene and protein expression of CK20 and CEA in non-macroscopically involved lymph nodes of colorectal cancer". Int. J. Surg. Pathol. 17 (2): 93–8. S2CID 3123711.
- Eissa S, Zohny SF, Swellam M, et al. (2008). "Comparison of CD44 and cytokeratin 20 mRNA in voided urine samples as diagnostic tools for bladder cancer". Clin. Biochem. 41 (16–17): 1335–41. PMID 18804101.
- Lugli A, Tzankov A, Zlobec I, Terracciano LM (2008). "Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status". Mod. Pathol. 21 (11): 1403–12. PMID 18587323.
- He H, Fang W, Liu X, et al. (2009). "Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases". Appl. Immunohistochem. Mol. Morphol. 17 (1): 40–6. S2CID 1735166.
- Stenling R, Lindberg J, Rutegírd J, Palmqvist R (2007). "Altered expression of CK7 and CK20 in preneoplastic and neoplastic lesions in ulcerative colitis". APMIS. 115 (11): 1219–26. S2CID 36381220.
- Takano K, Kojima T, Ogasawara N, et al. (2008). "Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro". J. Mol. Histol. 39 (3): 265–73. S2CID 10932276.
- Barbisan F, Santinelli A, Mazzucchelli R, et al. (2008). "Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur". Cancer. 112 (3): 636–44. S2CID 22838425.
- Lagoudianakis EE, Kataki A, Manouras A, et al. (2009). "Detection of epithelial cells by RT-PCR targeting CEA, CK20, and TEM-8 in colorectal carcinoma patients using OncoQuick density gradient centrifugation system". J. Surg. Res. 155 (2): 183–90. PMID 19645077.
- Ishida M, Kushima R, Okabe H (2009). "Aberrant expression of class III beta-tubulin in basal cell carcinoma of the skin". Oncol. Rep. 22 (4): 733–7. PMID 19724850.
- Qiao JL, Meng XK, Zhang JJ, et al. (2009). "[Expression of CK20 mRNA in the peripheral blood around postoperative chemotherapy in patients with gastric cancer and its clinical significance]". Zhonghua Wei Chang Wai Ke Za Zhi. 12 (1): 32–5. PMID 19145500.