Keratin 8
| KRT8 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
| ||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 12: 52.9 – 52.95 Mb | Chr 15: 101.91 – 101.91 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.
Utility as an immunohistochemical stain
neuroendocrine tumors.[6]
Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.[7]
Interactions
Keratin 8 has been shown to
PPL.[10]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170421 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049382 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 5978885.
- ISBN 1-84110-100-1.
- PMID 15501967.
- PMID 11788583.
- PMID 10809736.
- S2CID 25735126.
Further reading
- Moll R, Franke WW, Schiller DL, et al. (1983). "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells". Cell. 31 (1): 11–24. S2CID 33701361.
- Ljubimov AV, Bartek J, Couchman JR, et al. (1992). "Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies". Int. J. Cancer. 50 (4): 562–6. S2CID 40459741.
- Smedts F, Ramaekers F, Robben H, et al. (1990). "Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia". Am. J. Pathol. 136 (3): 657–68. PMID 1690513.
- Krauss S, Franke WW (1990). "Organization and sequence of the human gene encoding cytokeratin 8". Gene. 86 (2): 241–9. PMID 1691124.
- Yamamoto R, Kao LC, McKnight CE, Strauss JF (1990). "Cloning and sequence of cDNA for human placental cytokeratin 8. Regulation of the mRNA in trophoblastic cells by cAMP". Mol. Endocrinol. 4 (3): 370–4. PMID 1692965.
- Waseem A, Alexander CM, Steel JB, Lane EB (1991). "Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs". New Biol. 2 (5): 464–78. PMID 1705144.
- Tsubura A, Okada H, Sasaki M, et al. (1991). "Immunohistochemical demonstration of keratins 8 and 14 in benign tumours of the skin appendage". Virchows Archiv A. 418 (6): 503–7. S2CID 12052324.
- Leube RE, Bosch FX, Romano V, et al. (1987). "Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ". Differentiation. 33 (1): 69–85. PMID 2434381.
- Guelstein VI, Tchypysheva TA, Ermilova VD, et al. (1988). "Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer". Int. J. Cancer. 42 (2): 147–53. S2CID 30650956.
- Osborn M, Mazzoleni G, Santini D, et al. (1988). "Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas". Virchows Archiv A. 413 (4): 303–12. S2CID 23830197.
- Fisher HP, Doppl W, Osborn M, Altmannsberger M (1989). "Evidence for a hepatocellular lineage in a combined hepatocellular-cholangiocarcinoma of transitional type". Virchows Archiv B. 56 (2): 71–6. S2CID 24713975.
- Kulesh DA, Ceceña G, Darmon YM, et al. (1989). "Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8". Mol. Cell. Biol. 9 (4): 1553–65. PMID 2471065.
- Gel'shteĭn VI, Chipysheva TA, Ermilova VD, Bannikov GA (1990). "[The expression of keratins Nos. 8, 17 and vimentin in pleomorphic adenoma of the salivary glands]". Arkh. Patol. 51 (10): 28–35. PMID 2482017.
- Eichbaum QG, Beatty DW, Parker MI (1994). "Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera". J. Autoimmun. 7 (2): 243–61. PMID 8037842.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Ku NO, Omary MB (1997). "Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431". J. Biol. Chem. 272 (11): 7556–64. PMID 9054461.
- Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins". Electrophoresis. 18 (3–4): 605–13. S2CID 25454450.
- Liao J, Ku NO, Omary MB (1997). "Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells". J. Biol. Chem. 272 (28): 17565–73. PMID 9211903.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
External links
- Keratin-8 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)