L-765,314

Source: Wikipedia, the free encyclopedia.
L-765,314
Identifiers
  • benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate
JSmol)
  • CC(C)(C)NC(=O)[C@@H]1CN(CCN1C(=O)OCc2ccccc2)c3nc4cc(c(cc4c(n3)N)OC)OC
  • InChI=1S/C27H34N6O5/c1-27(2,3)31-24(34)20-15-32(11-12-33(20)26(35)38-16-17-9-7-6-8-10-17)25-29-19-14-22(37-5)21(36-4)13-18(19)23(28)30-25/h6-10,13-14,20H,11-12,15-16H2,1-5H3,(H,31,34)(H2,28,29,30)/t20-/m0/s1 ☒N
  • Key:CGWOIDCAGBKOQL-FQEVSTJZSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

L-765,314 is a drug which acts as a potent and selective

antagonist of the α1-adrenergic receptor subtype α1B.[1] It has mainly been used to investigate the role of α1B-adrenergic receptors in the regulation of blood pressure.[2][3] The α1B receptor is also thought to have an important role in the brain; however, L-765,314 does not cross the blood–brain barrier.[4]

References

  1. PMID 9548811
    .
  2. PMID 12233824
    .
  3. PMID 19376108
    .
  4. S2CID 8780600
    .


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