LGALS3BP
| LGALS3BP | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 78.97 – 78.98 Mb | Chr 11: 118.28 – 118.29 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.[5][6][7][8]
Function
The
beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.[8]
Clinical significance
LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (
natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity.[8]
Interactions
LGALS3BP has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000108679 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033880 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7698018.
- PMID 8034587.
- ^ PMID 8390986.
- ^ a b c "Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein".
- PMID 1917996.
- PMID 11146440.
Further reading
- Grassadonia A, Tinari N, Iurisci I, et al. (2004). "90K (Mac-2 BP) and galectins in tumor progression and metastasis". Glycoconj. J. 19 (7–9): 551–6. S2CID 8981436.
- Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S (1991). "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin". J. Biol. Chem. 266 (28): 18731–6. PMID 1917996.
- Yu B, Wright SD (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. 45 (2): 115–25. PMID 7583357.
- Koths K, Taylor E, Halenbeck R, et al. (1993). "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain". J. Biol. Chem. 268 (19): 14245–9. PMID 8390986.
- Inohara H, Akahani S, Koths K, Raz A (1996). "Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion". Cancer Res. 56 (19): 4530–4. PMID 8813152.
- Brakebusch C, Jallal B, Fusco O, et al. (1997). "Expression of the 90K immunostimulator gene is controlled by a promoter with unique features". J. Biol. Chem. 272 (6): 3674–82. PMID 9013622.
- Fusco O, Querzoli P, Nenci I, et al. (1998). "90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells". Int. J. Cancer. 79 (1): 23–6. PMID 9495353.
- Sasaki T, Brakebusch C, Engel J, Timpl R (1998). "Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin". EMBO J. 17 (6): 1606–13. PMID 9501082.
- Trahey M, Weissman IL (1999). "Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 3006–11. PMID 10077627.
- Tinari N, Kuwabara I, Huflejt ME, et al. (2001). "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". Int. J. Cancer. 91 (2): 167–72. PMID 11146440.
- Hellstern S, Sasaki T, Fauser C, et al. (2002). "Functional studies on recombinant domains of Mac-2-binding protein". J. Biol. Chem. 277 (18): 15690–6. PMID 11867635.
- Marchetti A, Tinari N, Buttitta F, et al. (2002). "Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients". Cancer Res. 62 (9): 2535–9. PMID 11980646.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. S2CID 581283.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. S2CID 11683986.
- Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile". Mol. Cell. Proteomics. 3 (7): 715–28. PMID 15084671.
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