LHX2
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| Location (UCSC) | Chr 9: 124 – 124.03 Mb | Chr 2: 38.23 – 38.26 Mb | |||||||
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LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[5][6][7]
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]
Interactions
LHX2 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106689 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000247 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8649822.
- PMID 10051612.
- ^ a b "Entrez Gene: LHX2 LIM homeobox 2".
- PMID 10593900.
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. PMID 12477932.
- Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–36167. PMID 10593900.
- Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–399. S2CID 22326394.
- Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity". Differentiation. 63 (3): 151–157. PMID 9697309.
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