LRRTM1
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| Location (UCSC) | Chr 2: 80.29 – 80.3 Mb | Chr 6: 77.22 – 77.23 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
LRRTM1 is a brain-expressed
leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).[7][8]
Clinical significance
LRRTM1 is the first gene linked to increased odds of being
mental illnesses such as schizophrenia, again only if inherited from the father's side.[9] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,[10]
indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.
LRRTM1 is also critically involved in synapse formation within the dorsal lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals. Lack of this gene shows decreased performance in complex visual tasks.[11]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162951 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060780 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 20519524.
- PMID 21953696.
- ^ "Entrez Gene: leucine rich repeat transmembrane neuronal 1".
- PMID 12676565.
- ^ PMID 17667961.
- "Gene for left-handedness is found". BBC News. 31 July 2007.
- S2CID 6285226.
- ^ Van Name, Jonathan; Monavarfeshani, Aboozar; Fox, Michael (July 2017). "The role of complex retinogeniculate synapses in mouse visual behavior".
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Further reading
- Leach EL, Prefontaine G, Hurd PL, Crespi BJ (June 2014). "The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population". Journal of Human Genetics. 59 (6): 332–6. S2CID 6285226.
- Sousa I, Clark TG, Holt R, Pagnamenta AT, Mulder EJ, Minderaa RB, et al. (March 2010). "Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry". Molecular Autism. 1 (1): 7. PMID 20678249.
- Crow TJ, Close JP, Dagnall AM, Priddle TH (January 2009). "Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007)". Laterality. 14 (1): 3–10. S2CID 770656.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. PMID 12975309.
- Ludwig KU, Mattheisen M, Mühleisen TW, Roeske D, Schmäl C, Breuer R, et al. (August 2009). "Supporting evidence for LRRTM1 imprinting effects in schizophrenia". Molecular Psychiatry. 14 (8): 743–5. S2CID 205201798.
- McManus C, Nicholls M, Vallortigara G (January 2009). "Editorial commentary: is LRRTM1 the gene for handedness?". Laterality. 14 (1): 1–2. S2CID 8667174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Francks C (January 2009). "Understanding the genetics of behavioural and psychiatric traits will only be achieved through a realistic assessment of their complexity". Laterality. 14 (1): 11–6. S2CID 17388449.