Lown–Ganong–Levine syndrome

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Lown–Ganong–Levine syndrome
Wolff-Parkinson-White syndrome
MedicationMedication, catheter ablation

Lown–Ganong–Levine syndrome (LGL) is a

William Francis Ganong, Jr., and Samuel A. Levine.[2][3]

Signs and symptoms

In general, patients will be asymptomatic at baseline. During their tachyarrhythmia however, they may report palpitations, shortness of breath, syncope or presyncope. They will have a tachycardia. How well they tolerate their tachyarrhythmia is dictated by their physiologic reserve. A young, well patient may just have palpitations and the tachycardia alone. However, an older patient with pre-existing (discrete) cardiovascular disease may additionally experience hypotension and syncope. Very fast heart rates can be detrimental even in well patients though.

Pathophysiology

LGL syndrome was originally thought to involve a rapidly conducting

His-Purkinje system, in most cases the short PR interval is caused by accelerated conduction through the atrioventricular node.[1] LGL syndrome is therefore felt to represent a clinical syndrome with multiple different underlying causes.[citation needed
]

Diagnosis

ECG recorded from a 17-year-old male with Lown-Ganong-Levine syndrome

LGL syndrome is diagnosed in a person who has experienced episodes of abnormal heart racing (arrhythmias) who has a PR interval less than or equal to 0.12 second (120 ms) with normal QRS complex configuration and duration on their resting ECG.[1] .[citation needed]

LGL can be distinguished from Wolff–Parkinson–White syndrome (WPW) syndrome because the delta waves seen in WPW syndrome are not seen in LGL syndrome. The QRS complex is often normal but can also be narrow in LGL syndrome, as opposed to WPW, because ventricular conduction is via the His-Purkinje system. Lown–Ganong–Levine syndrome is a clinical diagnosis that came about before the advent of electrophysiology studies. It is important to be aware that not all WPW ECGs have a delta wave; the absence of a delta wave does not conclusively rule out WPW.[citation needed]

Prognosis

Individuals with LGL syndrome do not carry an increased risk of sudden death. The only morbidity associated with the syndrome is the occurrence of paroxysmal episodes of tachycardia which may be of several types, including sinus tachycardia, atrioventricular nodal re-entrant tachycardia, atrial fibrillation, or atrial flutter.[4]

See also

References

  1. ^
    OCLC 938434294.{{cite book}}: CS1 maint: location missing publisher (link
    )
  2. ^ Rull G (2009). "Lown–Ganong–Levine Syndrome". Patient UK. EMIS. Retrieved 2011-05-29.
  3. PMID 14926053
    .
  4. PMID 6613890
    .

External links

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