MAGEA1

MAGEA1
	Gene ontology
Molecular function	histone deacetylase binding; protein binding;
Cellular component	cytoplasm; plasma membrane; nucleus;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000198681


n/a

UniProt


P43355


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RefSeq (mRNA)


NM_004988


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RefSeq (protein)


NP_004979


n/a

Location (UCSC)

Chr X: 153.18 – 153.18 Mb

n/a

PubMed search

^[2]

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Wikidata

View/Edit Human

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.^[3]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80%

chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 1840703
.

^ "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)".

Further reading

Takahashi K, Shichijo S, Noguchi M, et al. (1995). "Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis". Cancer Res. 55 (16): 3478–82.
PMID 7627949
.

Celis E, Fikes J, Wentworth P, et al. (1995). "Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles". Mol. Immunol. 31 (18): 1423–30.
PMID 7823968
.

De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9.
S2CID 11331427
.

Schultz-Thater E, Juretic A, Dellabona P, et al. (1994). "MAGE-1 gene product is a cytoplasmic protein". Int. J. Cancer. 59 (3): 435–9.
S2CID 11410139
.

Ding M, Beck RJ, Keller CJ, Fenton RG (1994). "Cloning and analysis of MAGE-1-related genes". Biochem. Biophys. Res. Commun. 202 (1): 549–55.
PMID 8037761
.

Wang MG, Zakut R, Yi H, et al. (1994). "Localization of the MAGE1 gene encoding a human melanoma antigen to chromosome Xq28". Cytogenet. Cell Genet. 67 (2): 116–9.
PMID 8039421
.

Becker JC, Gillitzer R, Bröcker EB (1994). "A member of the melanoma antigen-encoding gene (MAGE) family is expressed in human skin during wound healing". Int. J. Cancer. 58 (3): 346–8.
S2CID 43714786
.

Gaugler B, Van den Eynde B, van der Bruggen P, et al. (1994). "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes". J. Exp. Med. 179 (3): 921–30.
PMID 8113684
.

Chen YT, Stockert E, Chen Y, et al. (1994). "Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1004–8.
PMID 8302824
.

Rogner UC, Wilke K, Steck E, et al. (1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31.
PMID 8575766
.

Luescher IF, Romero P, Kuznetsov D, et al. (1996). "HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA-A29, and HLA-B44". J. Biol. Chem. 271 (21): 12463–71.
PMID 8647853
.

Tanzarella S, Russo V, Lionello I, et al. (1999). "Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family". Cancer Res. 59 (11): 2668–74.
PMID 10363990
.

Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75.
PMID 10854409
.

Jang SJ, Soria JC, Wang L, et al. (2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959–63.
PMID 11691819
.

Suyama T, Ohashi H, Nagai H, et al. (2003). "The MAGE-A1 gene expression is not determined solely by methylation status of the promoter region in hematological malignancies". Leuk. Res. 26 (12): 1113–8.
PMID 12443884
.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
PMID 12477932
.

Nagao T, Higashitsuji H, Nonoguchi K, et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity". J. Biol. Chem. 278 (12): 10668–74.
PMID 12525503
.

Zerbini A, Pilli M, Soliani P, et al. (2004). "Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma". J. Hepatol. 40 (1): 102–9.
PMID 14672620
.

Wang LP, Chen HS, Mei MH, et al. (2004). "[The genetic polymorphism of melanoma-associated antigen 1 in Chinese normal donors and hepatoma patients]". Zhonghua Gan Zang Bing Za Zhi. 12 (3): 151–5.
PMID 15059299
.

External links

Overview of all the structural information available in the PDB for UniProt: P43355 (Melanoma-associated antigen 1) at the PDBe-KB.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=MAGEA1&oldid=1193487415"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198681 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1840703-3] PMID 1840703
.

[entrez-4] "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)".

[2]

[3]

[4]