MYO1E

MYO1E
Available structures
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; actin filament binding; microfilament motor activity; protein binding; phosphatidylinositol binding; actin binding; cytoskeletal motor activity; ATP binding; lipid binding;
Cellular component	cytoplasm; cell-cell junction; clathrin-coated endocytic vesicle; adherens junction; cell junction; brush border; actin cytoskeleton; extracellular exosome; cytoskeleton; cytoplasmic vesicle; clathrin-coated vesicle; myosin complex;
Biological process	hemopoiesis; endocytosis; glomerular visceral epithelial cell development; glomerular basement membrane development; kidney development; post-embryonic hemopoiesis; in utero embryonic development; actin filament-based movement; vasculogenesis; nitrogen compound metabolic process; glomerular filtration; platelet-derived growth factor receptor signaling pathway; metabolism;
	Sources:Amigo / QuickGO
	ENSG00000157483
	ENSMUSG00000032220
	Q12965
	E9Q634
	NM_004998
	NM_181072; NM_025612
	NP_004989
	NP_851417
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.^[5]^[6]

Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. ^[7]

The MYO1E gene was included in several genetic signatures for cancer prognosis.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157483 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 8884266
.

^ "Entrez Gene: MYO1E myosin IE".

PMID 20471271
.

PMID 36329531
.

Further reading

Krendel M, Osterweil EK, Mooseker MS (February 2007). "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis". FEBS Letters. 581 (4): 644–650.
PMID 17257598
.

El Mezgueldi M, Tang N, Rosenfeld SS, Ostap EM (June 2002). "The kinetic mechanism of Myo1e (human myosin-IC)". The Journal of Biological Chemistry. 277 (24): 21514–21521.
PMID 11940582
.

Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motility and the Cytoskeleton. 41 (4): 308–324.
PMID 9858156
.

Robertson H, Langdon WY, Thien CB, Bowtell DD (November 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochemical and Biophysical Research Communications. 240 (1): 46–50.
PMID 9367879
.

Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (July 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–6553.
PMID 8022818
.

Bement WM, Wirth JA, Mooseker MS (October 1994). "Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain". Journal of Molecular Biology. 243 (2): 356–363.
PMID 7932763
.

External links

Overview of all the structural information available in the PDB for UniProt: E9Q634 (Mouse Unconventional myosin-Ie) at the PDBe-KB.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=MYO1E&oldid=1188149720"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157483 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032220 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884266-5] PMID 8884266
.

[entrez-6] "Entrez Gene: MYO1E myosin IE".

[7] PMID 20471271
.

[ChiccoAlameerRahmati2022-8] PMID 36329531
.

[3]

[4]

[5]

[6]

[7]

[8]