Malaprade reaction

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In

carbonyl functional groups.[1][2]
The reaction was first reported by Léon Malaprade in 1928. Amino alcohols are also cleaved.

In terms of mechanism, the reaction is thought to proceed by a cyclic diester of iodine(VII).[3]

See also

References

  1. doi:10.15227/orgsyn.072.0006
    .
  2. doi:10.1002/9780470638859.conrr406
    .
  3. ISBN 978-0-471-72091-1

Historic references

  • Dupuis, Gérard. "Les alcools" [Alcohols]. Cours de chimie Organique (in French). Lycée Faidherbe de Lille. Les α-glycols subissent une réaction de coupure en présence d'acide périodique HIO4 pour donner des composés carbonylés. Il s'agit de la réaction introduite en 1928 par le chimiste français L. Malaprade et qui porte son nom. [In the presence of periodic acid, HIO4, α-glycols react, cleaving into their component carbonyls.]
  • L. Malaprade (1928). Bull. Soc. Chim. France. 43: 683. {{cite journal}}: Missing or empty |title= (help)
  • Compt. Rend. 186: 382. 1928. {{cite journal}}: Missing or empty |title= (help)
  • Nicolet, Ben H.; Shinn, Leo A. (1939). "The Action of Periodic Acid on α-Amino Alcohols".
    doi:10.1021/ja01875a521
    .


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