Mixed tumor
A mixed tumor is a tumor that derives from multiple tissue types.[1] A biplastic tumor or biphasic tumor has two tissue types.[2][3]
True versus false
- A true mixed tumor contains multiple types of
- A "false" mixed tumor contains one type of neoplastic cells, but which have more than one appearance. For example, benign pleomorphic salivary gland tumors may have some tumors cells that form pseudocartilage. Yet, all the tumor cells have similar myoepithelial profile on immunohistochemistry, and are thus classified as one cell type.
Reactive or adaptive changes to a tumor does not count towards a classification as mixed. Such changes include angiogenesis (blood vessel proliferation) and/or desmoplasia (proliferation of connective tissue).[5]
Number of cell types
Examples of true mixed tumors
| Disease | Cellular elements | |
|---|---|---|
| Fibroadenoma[7] | Epithelium | Stroma |
| Ceruminous adenoma[8] | Inner luminal secretory cells | Myoepithelial cells |
| Carcinosarcoma[9] | Carcinomatous cells | Sarcomatous cells |
References
- ^ a b "mixed tumor". TheFreeDictionary (by Farlex). Retrieved 2020-04-26. In turn citing:
-For requiring neoplastic types: Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition
- Without further specification:
- Farlex Partner Medical Dictionary - ^ PMID 33729177.
- ^ PMID 24701553.
- ISSN 0893-3952.
- ISSN 0893-3952.
- ^ "NCI Dictionary of Cancer Terms". National Cancer Institute. 2011-02-02. Retrieved 20 December 2017.
- ISBN 978-92-832-2412-9.
- PMID 15104293.
- ^ M Sherif Said. "Pathology of True Malignant Mixed Tumor (Carcinosarcoma)". Medscape. Updated: Dec 01, 2015
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