NDUFB5
| NDUFB5 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 3: 179.6 – 179.63 Mb | Chr 3: 32.79 – 32.81 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa is a
mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.[6]
Structure
The NDUFB5 gene, located on the q arm of
NADH dehydrogenase (ubiquinone) complex at the inner mitochondrial membrane.[5]
Function
The human NDUFB5 gene codes for a subunit of
isoalloxazine ring of the flavin mononucleotide (FMN) prosthetic arm to form FMNH2. The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH2). The flow of electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136521 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027673 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa".
- ^ ISBN 978-0-470-54784-7.
- PMID 23965338.
- ^ "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).
- ^ "NDUFB5 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5". UniProt: a hub for protein information. The UniProt Consortium. Retrieved 2 April 2015.