NOM1
| NOM1 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 7: 156.95 – 156.97 Mb | Chr 5: 29.64 – 29.66 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Nucleolar protein with MIF4G domain 1 is a protein that in humans is encoded by the NOM1 gene.[5]
Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases.[6][5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000146909 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001569 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Nucleolar protein with MIF4G domain 1". Retrieved 2011-09-27.
- PMID 15715967.
Further reading
- Heus HC, Hing A, van Baren MJ, Joosse M, Breedveld GJ, Wang JC, et al. (May 1999). "A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36". Genomics. 57 (3): 342–351. PMID 10329000.
- Simmons HM, Ruis BL, Kapoor M, Hudacek AW, Conklin KF (February 2005). "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia". Gene. 347 (1): 137–145. PMID 15715967.
- Gunawardena SR, Ruis BL, Meyer JA, Kapoor M, Conklin KF (January 2008). "NOM1 targets protein phosphatase I to the nucleolus". The Journal of Biological Chemistry. 283 (1): 398–404. PMID 17965019.
- Alexandrov A, Colognori D, Steitz JA (May 2011). "Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex". Genes & Development. 25 (10): 1078–1090. PMID 21576267.
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