proteins that in humans consists of 3 proteins (NOTCH2NLA, NOTCH2NLB, and NOTCH2NLC) and is encoded by NOTCH2NLgene. It appears to play a key role in the development of the prefrontal cortex, a part of the brain.[3][4][5][6]
NOTCH2NL increases the number of
organoids leads to the organoids being smaller, while resulting in premature differentiation of cortical stem cells into neurons.[5]
The role of NOTCH2NL in the development of the human brain together with the evolutionary history of NOTCH2NL genes, suggests that the emergence of NOTCH2NL genes may have contributed to the increase in size of the human neocortex which tripled over the last two million years.
