NPRL3

NPRL3
Identifiers
Gene ontology
Molecular function	GTPase activator activity; protein binding;
Cellular component	GATOR1 complex; lysosome; lysosomal membrane; membrane;
Biological process	negative regulation of TOR signaling; cellular response to amino acid starvation; roof of mouth development; ventricular septum development; aorta morphogenesis; cardiac muscle tissue development; positive regulation of GTPase activity; TORC1 signaling; regulation of autophagosome assembly;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000103148


ENSMUSG00000020289

UniProt


Q12980


Q8VIJ8

RefSeq (mRNA)

NM_001039476 NM_001077350 NM_001243247 NM_001243248 NM_001243249
NM_012075


NM_001284359 NM_001284360 NM_181569

RefSeq (protein)


NP_001034565 NP_001070818 NP_001230176 NP_001230177 NP_001230178


NP_001271288 NP_001271289 NP_853547

Location (UCSC)

Chr 16: 0.08 – 0.14 Mb

Chr 11: 32.18 – 32.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nitrogen permease regulator-like 3 is a protein that in humans is encoded by the NPRL3 gene.^[5]

Function

NPRL3 is a human protein of poorly understood function^[6] but has been associated with cancer.

The most prominent function ascribed to Nprl3 to date is as part of the GATOR1 complex

Rag GTPase complex. Additionally, Nprl3 has been shown to adjust cell metabolism via the TOR pathway, and this is important for development of the cardiovascular system in mammals.^[6] Without this effect, spontaneous cell apoptosis would occur. A similar function for Nprl3 has been identified in the female reproductive system of Drosophila during times of protein scarcity.^[8]

Gene

In

erythrocytes accompanying hemoglobin production.^[6]

Structure

The human nitrogen permease regulator-like 3 protein has 569
amino acids
.

Domains

There is a predicted N-terminal longin
helix turn helix (HTH) domains.^[11]
These regions are predicted bind to another macromolecule, which could be DNA, RNA or protein.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103148 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020289 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: Nitrogen permease regulator-like 3 (S. cerevisiae)".

^
S2CID 231078
.

PMID 23723238
.

^ Youheng, Wei. "The Drosophila Nprl2/Nprl3 complex controls the response to nutrient stress by modulating TORC1 activity" (PDF). National Institute of Health. NICHD. Retrieved 19 March 2015.

PMID 19666006
.

PMID 15998734
.

PMID 23248642
.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.
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Retrieved from "https://en.wikipedia.org/w/index.php?title=NPRL3&oldid=1157873870"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103148 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020289 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nitrogen permease regulator-like 3 (S. cerevisiae)".

[Kowalczyk-6] 
S2CID 231078
.

[7] PMID 23723238
.

[8] Youheng, Wei. "The Drosophila Nprl2/Nprl3 complex controls the response to nutrient stress by modulating TORC1 activity" (PDF). National Institute of Health. NICHD. Retrieved 19 March 2015.

[pmid19666006-9] PMID 19666006
.

[pmid15998734-10] PMID 15998734
.

[pmid23248642-11] PMID 23248642
.

[3]

[4]

[5]

[6]

[8]

[11]