Nicastrin
Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene.[5][6][7]
Function
Nicastrin (abbreviated NCT) is a
PSEN1 (presenilin-1), which is the catalytically active component of the complex, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer 2).[8] Nicastrin itself is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the complex, all of which undergo significant post-translational modification before becoming active in the cell.[9] Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.[10]
History
The protein was named after the Italian country
familial Alzheimer's disease (FAD).[11]
Interactions
Nicastrin has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162736 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003458 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: NCSTN nicastrin".
- PMID 9039502.
- S2CID 4339220.
- S2CID 17324271.
- PMID 15711015.
- S2CID 26983263.
- S2CID 32600780.
- ^ S2CID 4339220.
- PMID 15257293.
- S2CID 53205510.
- PMID 12471034.
- ^ PMID 12297508.
External links
- nicastrin+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)