Nitromemantine

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Nitromemantine
Identifiers
  • 3-amino-5,7-diethyladamantan-1-yl nitrate
JSmol)
  • N[C@@]12C[C@]3(O[N+]([O-])=O)C[C@@](C2)(CC)C[C@@](C1)(CC)C3

Nitromemantine (developmental code name YQW-36) is a derivative of

glutamatergic system, by blocking NMDA receptors.[1][2]

Pharmacology

Like memantine, nitromemantine is a low-affinity voltage-dependent

glutamate, and consequent excitotoxicity. By blocking extrasynaptic NMDA receptors, nitromemantine is able to largely prevent this excitotoxicity while minimising the side effects usually seen with less selective NMDA antagonists.[3] The nitrate group of nitromemantine was found to bind to a second site on the extrasynaptic NMDA receptor which had previously been targeted with nitroglycerin, and this double action is thought to be responsible for the increased effectiveness of nitromemantine.[4]

See also

References

  1. S2CID 21379258
    .
  2. PMID 20060165
    .
  3. PMID 23776240
    .
  4. ^ Lieberman B (June 17, 2013). "Reversing the loss of brain connections in Alzheimer's disease". Beaker. Sanford-Burnham Science Blog.
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