Nojirimycin

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Nojirimycin
Names
IUPAC name
(3R,4S,5R,6R)-6-(Hydroxymethyl)-2,3,4,5-piperidinetetrol
Identifiers
3D model (
JSmol
)
ChEBI
ChemSpider
KEGG
UNII
  • InChI=1S/C6H13NO5/c8-1-2-3(9)4(10)5(11)6(12)7-2/h2-12H,1H2/t2-,3-,4+,5-,6?/m1/s1
    Key: BGMYHTUCJVZIRP-GASJEMHNSA-N
  • C([C@@H]1[C@H]([C@@H]([C@H](C(N1)O)O)O)O)O
Properties
C6H13NO5
Molar mass 179.172 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Nojirimycin is the parent compound of a class of

glycosidase inhibitors. Nojirimycin and its derivatives are mainly obtained from a class of Streptomyces species.[1] Chemically, it is an iminosugar
.

Derivatives

  • 1-deoxynojirimycin
    or duvoglustat
  • 1-deoxygalactonojirimycin
    or migalastat, a drug for the treatment of Fabry disease

References

  1. PMID 5636917
    .


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