Olorofim

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Olorofim
Clinical data
Other namesF901318
Legal status
Legal status
  • Investigational
Identifiers
  • 2-(1,5-Dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC28H27FN6O2
Molar mass498.562 g·mol−1

Olorofim (F901318) is an experimental antifungal drug being developed for invasive mold infections.[1][2] If approved it would be a first-in-class medication (for the orotomide class). In 2023, the FDA decided not to approve the drug and to request more data about the safety of the drug.[3] Olorofim does not inhibit growth of Candida species.[2]

References

  1. S2CID 258135111
    .
  2. ^
    PMID 32751765
    .
  3. ^ "FDA Passes on Olorofim Despite Critical Need for Antifungals". Medscape.
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