Orotomide

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Chemical structure of the orotomide F901318

Orotomides are a class of experimental

Proceedings of the National Academy of Sciences.[3] It was found to be effective against most important human fungal infections including those with Aspergillus, Lemontospora (Scedosporium) prolificans, Fusarium, Penicillium spp., and Taloromyces. The most promising drug candidate is designated F901318, chemical name 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoro-pyrimidin-2-yl)piperazin-1-yl]-phenyl}-2-oxo-acetamide. F901318 has been named Olorofim.[4]

Unlike other antifungal drugs, the orotomides act differently by stopping

orotate. This inhibition in turn block the growth of hyphae. This unique action makes it more effective than other antifungal drugs.[5] Originally named the F3 series, the name was changed to orotomides, combining the names of the compound (dihydroorotate) they acted upon with the chemical group (α-ketoamide) which they belong to.[3]

The European Medicines Agency (EMA) Committee for Orphan Medicinal Products granted orphan designation to F2G for F901318 for the treatment of scedosporiosis on 29 August 2016,[6] and for invasive aspergillosis on 14 October 2016.[7] As of May 2017, F901318 is in late phase 1 clinical trials.[8] It was shown to be useful for acute sinopulmonary aspergillosis caused by Aspergillus flavus.[9]

References

  1. ^ Birch, Michael (19 September 2015). "The antifungal activity of F901318, a new antifungal agent from the novel orotomide class". www.asm.org. American Society For Microbiology. Retrieved 8 October 2017.
  2. ^ Oliver, J.; Law, D.; Sibley, G.; Kennedy, A.; Birch, M. "F901318, a Novel Antifungal Agent from the Orotomide Class: Discovery and Mechanism of Action". Aspergillus & Aspergillosis Website. Retrieved 9 October 2017.
  3. ^
    PMID 27791100
    .
  4. PMID 29941638
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  5. PMID 28830945
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  6. ^ "EU/3/16/1713 Orphan designation". European Medicines Agency. Retrieved 9 October 2017.
  7. ^ "EU/3/16/1738 Orphan designation". European Medicines Agency. Retrieved 9 October 2017.
  8. ^ "Drug Profile F 901318". Adis Insight. Springer International Publishing AG. Retrieved 9 October 2017.
  9. PMID 28968675
    .
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