PDE2A

PDE2A
	Gene ontology
Molecular function	nucleotide binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; calcium channel activity; cGMP binding; metal ion binding; cyclic-nucleotide phosphodiesterase activity; protein binding; phosphoric diester hydrolase activity; TPR domain binding; hydrolase activity; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cAMP binding; protein homodimerization activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; identical protein binding; magnesium ion binding; zinc ion binding; phosphate ion binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; plasma membrane; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; presynaptic membrane; nucleus; mitochondrial outer membrane; mitochondrial inner membrane; mitochondrial matrix;
Biological process	establishment of endothelial barrier; cellular response to transforming growth factor beta stimulus; positive regulation of inflammatory response; cellular response to cGMP; negative regulation of transcription by RNA polymerase II; monocyte differentiation; cGMP-mediated signaling; cellular response to macrophage colony-stimulating factor stimulus; cellular response to mechanical stimulus; positive regulation of vascular permeability; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cAMP-mediated signaling; signal transduction; negative regulation of vascular permeability; cGMP catabolic process; cAMP catabolic process; calcium ion transmembrane transport; G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling; cellular response to cAMP; cellular response to 2,3,7,8-tetrachlorodibenzodioxine; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of gene expression; negative regulation of cGMP-mediated signaling; regulation of mitochondrion organization; heart valve development; ventricular septum development; aorta development;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000186642


ENSMUSG00000030653

UniProt


O00408


Q922S4

RefSeq (mRNA)


NM_001143839 NM_001146209 NM_001243784 NM_002599


NM_001008548 NM_001143848 NM_001143849 NM_001243757 NM_001243758

RefSeq (protein)


NP_001137311 NP_001139681 NP_001230713 NP_002590


NP_001008548 NP_001137320 NP_001137321 NP_001230686 NP_001230687

Location (UCSC)

Chr 11: 72.58 – 72.67 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186642 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 9210593
.

^ "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

Further reading

Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, Van Laak V (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. 37 (9): 584–590.
S2CID 1060183
.

Seybold J, Thomas D, Witzenrath M, Boral S, Hocke AC, Bürger A, Hatzelmann A, Tenor H, Schudt C (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9): 3569–3576.
PMID 15650061
.

Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45.
PMID 14702039
.

Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903.
PMID 12477932
.

Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265.
PMID 12271124
.

Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9.
S2CID 4637804
.

Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491.
S2CID 26315564
.

Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906.
PMID 10375378
.

v
t
e
PDB gallery

1mc0: Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains

1z1l: The Crystal Structure of the Phosphodiesterase 2A Catalytic Domain

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
v
t
e

Retrieved from "https://en.wikipedia.org/w/index.php?title=PDE2A&oldid=1199609548"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186642 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9210593-4] PMID 9210593
.

[entrez-5] "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

[2]

[3]

[4]

[5]