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There is a page named "PDE4B" on Wikipedia
5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. This gene is a member of the type IV, cyclic AMP (cAMP)-specific,...12 KB (1,442 words) - 22:09, 27 March 2024
inhibitors. Similarly PDE4B inhibition appears to be required for the antipsychotic effects of PDE4 inhibitors, in line with this view PDE4B polymorphisms and...18 KB (1,897 words) - 12:41, 23 February 2025- least four types of the enzyme phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'-cyclic-AMP phosphodiesterase Phosphodiesterase (PDE) PDE4...290 bytes (59 words) - 11:15, 2 July 2022
phosphodiesterase 4B (PDE4B), which causes inflammation. Chemically, crisaborole is a phenoxybenzoxaborole. Inhibition of PDE4B appears to suppress the...11 KB (940 words) - 03:02, 22 October 2024
(December 2023). "Next Generation PDE4 Inhibitors that Selectively Target PDE4B/D Subtypes: A Narrative Review". Dermatology and Therapy. 13 (12): 3031–3042...2 KB (79 words) - 08:15, 12 September 2024- Q14432 11861 PDE3B HGNC:8779 Q13370 11862 PDE4A HGNC:8780 P27815 11863 PDE4B HGNC:8781 Q07343 11864 PDE4C HGNC:8782 Q08493 11865 PDE4D HGNC:8783 Q08499...282 KB (17 words) - 09:28, 10 February 2025
of the phosphodiesterase PDE4. It displays a significant preference for PDE4B over PDE4A. Imperatorin has been shown to have anti-inflammatory activity...7 KB (578 words) - 09:11, 14 April 2023
Houslay, MD; Blackwood, DHR; Muir, WJ; Porteous, DJ (1993). "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling"...12 KB (913 words) - 03:30, 7 April 2025- cortex (DL-PFC) "plays a key role in problem solving." Freeman says that PDE4B has a detrimental effect on memory formation. Interviewed experts: Jason...93 KB (1,711 words) - 14:12, 3 March 2025
- chronic psychiatric illnesses, the gene that encodes phosphodiesterase 4B (PDE4B) is disrupted by a balanced translocation. The reasons for the relative...21 KB (2,440 words) - 06:32, 10 February 2025
domain include: PDE1A, PDE1B, PDE1B2, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4B5, PDE4C, PDE4D, PDE5A, PDE6A, PDE6B, PDE6C, PDE7A, PDE7B, PDE8A,...7 KB (821 words) - 20:38, 7 December 2023- parts: A saddle formed by the conserved glutamine (Q817 in PDE5A, Q443 in PDE4B and Q369 in PDE4D) and the P clamp (a hydrophobic clamp at the narrow side...42 KB (4,751 words) - 22:53, 8 March 2025
with inhibitors residing in the active site. The co-crystal structures for PDE4B, PDE4D and PDE5A have revealed two common features of inhibitor binding...25 KB (2,872 words) - 02:43, 7 March 2023- been dead for 20 years. By altering a single gene, phosphodiesterase-4B (PDE4B), researchers have increased the intelligence of mice, while decreasing...249 KB (24,022 words) - 04:11, 15 March 2025
researchers. Among its known interaction partners are 14-3-3ε, LIS1 and the PDE4B enzyme. DISC1 may play an important role in neuroplasticity via interactions...39 KB (4,723 words) - 06:28, 29 March 2024
