PI(4,5)P2 Cycle

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The PI(4,5)P2 cycle or simply PIP2 cycle (also known as PI cycle in past) is one of the important

GPCR signaling, cytokinesis,[1] endocytosis,[2] and apoptosis.[3]

Signalling steps

General PI(4,5)P2 cycle

PIP2 cycle involves steps of chemical reactions characterized by various enzymes. First hydrolysis of PIP2 molecules by activated

diacylglycerol and inositol trisphosphate. These two are themselves important second messengers.[4] Diacylglycerol further converted into phosphatidic acid (PA) by DAGK enzyme. Furthermore, CDP-diacylglycerol synthetase uses CTP to create cytidine diphosphate diacylglycerol from PA.[5][6] Generated CDP-DAG then condensed to PI by phosphatidylinositol synthase.[7] This PI is then phosphorylated to PI4P and back to PIP2 via action of PI4K and PIP5K[8]

References

  1. S2CID 37783775
    .
  2. PMID 23097040
    .
  3. PMID 11042212
    .
  4. S2CID 4242836
    .
  5. ^ Christie, William (Bill) W. "Cytidine Diphosphate Diacylglycerol (CDP-DAG), phospholipid biosynthesis - composition and biochemistry". www.lipidhome.co.uk. Retrieved 19 July 2021.
  6. PMID 24603715
    .
  7. PMID 22075144
    .
  8. S2CID 25453017
    . Retrieved 3 August 2017 – via jcs.biologists.org.
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