PNU-142633
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Preferred IUPAC name
(1S)-1-{2-[4-(4-Carbamoylphenyl)piperazin-1-yl]ethyl}-N-methyl-3,4-dihydro-1H-2-benzopyran-6-carboxamide | |
Other names
PNU-142633F
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Identifiers | |
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3D model (
JSmol ) |
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ChemSpider | |
PubChem CID
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UNII |
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CompTox Dashboard (EPA)
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Properties | |
C24H30N4O3 | |
Molar mass | 422.529 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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PNU-142633 is an experimental drug candidate for the treatment of
affinity 5-HT1D receptor antagonist.[1][2] PNU-142633 is well tolerated after oral administration.[3]
It was an interesting candidate due to its greater affinity for 5-HT1D compared to 5-HT1B receptors (typical migraine drugs such as triptans are agonists for both receptors), but experimental results were disappointing.[4]
The structure can be compared favorably with Sonepiprazole.
References
- PMID 10385247.
- ^ PNU 142633, Santa Cruz Biotechnology
- PMID 10543315.
- OCLC 1105199268.)
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