PPP1R13B
| PPP1R13B | |||
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| Location (UCSC) | Chr 14: 103.73 – 103.85 Mb | Chr 12: 111.79 – 111.87 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.[5][6]
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000088808 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021285 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9872452.
- ^ a b "Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B".
Further reading
- Liu ZJ, Lu X, Zhong S (2005). "ASPP--Apoptotic specific regulator of p53". Biochim. Biophys. Acta. 1756 (1): 77–80. PMID 16139958.
- PMID 11684014.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. PMID 12508121.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Bergamaschi D, Samuels Y, Jin B, et al. (2004). "ASPP1 and ASPP2: common activators of p53 family members". Mol. Cell. Biol. 24 (3): 1341–50. PMID 14729977.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. PMID 15231748.
- Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F". Cell Death Differ. 12 (4): 377–83. PMID 15706352.
- Fogal V, Kartasheva NN, Trigiante G, et al. (2005). "ASPP1 and ASPP2 are new transcriptional targets of E2F". Cell Death Differ. 12 (4): 369–76. PMID 15731768.
- Liu ZJ, Lu X, Zhang Y, et al. (2005). "Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53". FEBS Lett. 579 (7): 1587–90. S2CID 34118663.
- Bergamaschi D, Samuels Y, Zhong S, Lu X (2005). "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation". Oncogene. 24 (23): 3836–41. PMID 15782125.
- Agirre X, Román-Gómez J, Jiménez-Velasco A, et al. (2006). "ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia" (PDF). Oncogene. 25 (13): 1862–70. PMID 16314841.
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