PPP2R2B
| PPP2R2B | |||
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Gene ontology | |||
| Molecular function | |||
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| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | Chr 5: 146.58 – 147.08 Mb | Chr 18: 42.77 – 43.22 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.[5][6]
The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major
autosomal dominant spinocerebellar ataxia 12.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000156475 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024500 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1849734.
- S2CID 33491731.
- ^ "Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform".
Further reading
- Millward TA, Zolnierowicz S, Hemmings BA (1999). "Regulation of protein kinase cascades by protein phosphatase 2A". Trends Biochem. Sci. 24 (5): 186–91. PMID 10322434.
- Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res. 3 (1): 43–51. PMID 15638722.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Schalling M, Hudson TJ, Buetow KH, Housman DE (1993). "Direct detection of novel expanded trinucleotide repeats in the human genome". Nat. Genet. 4 (2): 135–9. S2CID 13281635.
- Tung HY, De Rocquigny H, Zhao LJ, et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. S2CID 23293768.
- Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. PMID 9400615.
- Strack S, Zaucha JA, Ebner FF, et al. (1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". J. Comp. Neurol. 392 (4): 515–27. S2CID 20496320.
- Fujigasaki H, Verma IC, Camuzat A, et al. (2001). "SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family". Ann. Neurol. 49 (1): 117–21. S2CID 20499068.
- Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. PMID 11531413.
- Guo CY, Brautigan DL, Larner JM (2002). "ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation". J. Biol. Chem. 277 (7): 4839–44. PMID 11723136.
- Bennin DA, Don AS, Brake T, et al. (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. PMID 11956189.
- Okamoto K, Li H, Jensen MR, et al. (2002). "Cyclin G recruits PP2A to dephosphorylate Mdm2". Mol. Cell. 9 (4): 761–71. PMID 11983168.
- Marmorstein LY, McLaughlin PJ, Stanton JB, et al. (2002). "Bestrophin interacts physically and functionally with protein phosphatase 2A". J. Biol. Chem. 277 (34): 30591–7. PMID 12058047.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. PMID 12110603.
External links
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