PPP3CC
| PPP3CC | |||
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| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 8: 22.44 – 22.54 Mb | Chr 14: 70.22 – 70.29 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.[5][6]
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status.
In testis, the motility of the
holoenzyme
is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.
At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM][6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000120910 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022092 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1339277.
- ^ a b "Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform".
Further reading
- Esau C, Boes M, Youn HD, et al. (2001). "Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells". J. Exp. Med. 194 (10): 1449–59. PMID 11714752.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Bennasser Y, Badou A, Tkaczuk J, et al. (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. PMID 12482669.
- Gerber DJ, Hall D, Miyakawa T, et al. (2003). "Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8993–8. PMID 12851458.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. S2CID 39457788.
- Eastwood SL, Burnet PW, Harrison PJ (2005). "Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia". Biol. Psychiatry. 57 (7): 702–10. S2CID 39744063.
- Kinoshita Y, Suzuki T, Ikeda M, et al. (2006). "No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia". Journal of Neural Transmission. 112 (9): 1255–62. S2CID 143604.
- Liu YL, Fann CS, Liu CM, et al. (2008). "More evidence supports the association of PPP3CC with schizophrenia". Mol. Psychiatry. 12 (10): 966–74. PMID 17339875.
- Horiuchi Y, Ishiguro H, Koga M, et al. (2008). "Support for association of the PPP3CC gene with schizophrenia". Mol. Psychiatry. 12 (10): 891–3. PMID 17895921.
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