PRIMA1
| PRIMA1 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl |
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|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | n/a | Chr 12: 103.16 – 103.21 Mb | |||||||
| PubMed search | [2] | [3] | |||||||
| View/Edit Human | View/Edit Mouse |
Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene.[4][5]
Function
PRiMA functions to organize
C-terminal T-peptide of AChE.[7]
PRiMA plays a role in targeting AChE to the cell surface and, in neuroblastoma cells, PRiMA the limiting factor of such targeting.[5] In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.
Clinical significance
The severity of neurogenerative diseases, such as Alzheimer’s, can be related to the degradation of AChE.[8]
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041669 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: proline rich membrane anchor 1".
- ^ PMID 11804574.
- PMID 16429581.
- S2CID 21808922.
- S2CID 45149066.
Further reading
- Vanaja DK, Ballman KV, Morlan BW, Cheville JC, Neumann RM, Lieber MM, Tindall DJ, Young CY (Feb 2006). "PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer". Clinical Cancer Research. 12 (4): 1128–36. PMID 16489065.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Xie HQ, Choi RC, Leung KW, Chen VP, Chu GK, Tsim KW (Apr 2009). "Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation". Brain Research. 1265: 13–23. S2CID 26943639.
- Xie HQ, Liang D, Leung KW, Chen VP, Zhu KY, Chan WK, Choi RC, Massoulié J, Tsim KW (Apr 2010). "Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons". The Journal of Biological Chemistry. 285 (15): 11537–46. PMID 20147288.
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