Pamela Silver
Pamela Silver | |
---|---|
Born | Pamela Ann Silver |
Nationality | American |
Alma mater | |
Scientific career | |
Fields | Synthetic biology Systems biology[1] |
Institutions | |
Thesis | Mechanisms of membrane assembly : studies on the association of an integral protein with biological membranes (1982) |
Doctoral advisor | William T. Wickner |
Doctoral students | Christina Agapakis[2] Valerie Weiss |
Other notable students | Karmella Haynes Jessica Polka Anita Corbett |
Website | www |
Pamela Ann Silver is an American cell and systems biologist and a bioengineer. She holds the Elliot T. and Onie H. Adams Professorship of Biochemistry and Systems Biology at Harvard Medical School in the Department of Systems Biology.[1][3] Silver is one of the founding Core Faculty Members of the Wyss Institute for Biologically Inspired Engineering at Harvard University.[4][5]
She has made contributions to other disciplines including cell and nuclear biology,[6][7][8] systems biology,[9][10] RNA biology,[11][12][13] cancer therapeutics,[14] international policy research, and graduate education. Silver was the first director of the Harvard University Graduate Program in Systems Biology.[15] She serves as a member of the National Science Advisory Board for Biosecurity.[16]
Education and early life
Silver grew up in Atherton, California, where she attended Laurel and Encinal Elementary Schools. During this time, she was a winner of the IBM Math Competition, winning a slide rule[17] and received special recognition for her early aptitude in science. She attended Menlo Atherton High School and graduated from Castilleja School in Palo Alto. She received her B.A. in chemistry from the University of California, Santa Cruz and her PhD in Biological Chemistry from the University of California, Los Angeles in 1982 in the laboratory of William T. Wickner, working largely on the coat assembly of the M13 coliphage.[18][19]
Career and research
Silver did her
Silver continued in the area of Cell Biology upon moving to the
In 2004, Silver moved to the newly formed Department of Systems Biology at
Her former students include Christina Agapakis,[2] Valerie Weiss, Karmella Haynes, Jessica Polka and Anita Corbett[29]
Synthetic Biology
Some of Silver's work in this area includes the engineering of: mammalian cells to remember and report past exposures to drugs and radiation,[30][31][32] robust computational circuits in embryonic stem cells and bacteria,[33] and synthetic switches to moderate gene silencing with the integration of novel therapeutic proteins.[34][35] Silver's work sets the stage for the development of novel therapies for use in both humans and animals.
Carbon fixation and sustainability
Silver has characterized the carboxysome – the major carbon-fixing structure in cyanobacteria – to enhance photosynthetic efficiency[36] and carbon fixation.[37] She has also engineered cyanobacteria to more efficiently cycle carbon into high-value commodities and has shown that these bacteria can form sustainable consortia.[38] In a collaboration with Jessica Polka, Silver performed super-resolution microscopy of the β-carboxysome.[39]
Silver collaborated with
Gene regulation
Silver discovered a correlation between nuclear transport and gene regulation – she identified the first arginine methyltransferase, which plays a role in chromatin function and is important to the movement of RNA binding proteins between the nucleus and cytoplasm of cells. She also discovered previously unknown variations among ribosomes that led her to propose a unique specificity for the matching between ribosomes and the subsequent translation of mRNAs. Silver's finding has several implications for our understanding of how gene regulation impacts disease development, such as cancer.[41]
Awards and honors
Silver has been the recipient of an NSF Presidential Young Investigator Award, a Basil O’Connor Research Scholar of the March of Dimes, an Established Investigator of the American Heart Association, the NIH Directors Lecture, and NIH MERIT award, Innovation award at BIO, a Fellow of the
Silver was awarded the BBS Mentoring Award for Graduate Education at Harvard Medical School. She is also one of the founders of the International Genetically Engineered Machines competition (iGEM) and currently sits on the Board of iGEM.org. Silver founded and was the first Director of the Harvard University Graduate Program in Systems Biology. Silver was elected to the American Academy of Arts and Sciences in 2017[42] and the National Academy of Sciences in 2023.
References
- ^ a b Pamela Silver publications indexed by Google Scholar
- ^ ProQuest 881069635.
- ^ Pamela Silver publications from Europe PubMed Central
- ^ Silver profile page, Wyss Institute
- ^ Systems Biology PhD Program
- PMID 7568202.
- PMID 6091123.
- S2CID 8932425.
- S2CID 16841542.
- S2CID 25722385.
- PMID 20705336.
- PMID 9499403.
- PMID 8675010.
- PMID 14706338.
- ^ http://sysbiophd.harvard.edu
- ^ "National Science Advisory Board for Biosecurity (NSABB)". Office of Science Policy. Retrieved January 16, 2021.
- ^ "Harvard's Pamela Silver recalls journey from Silicon Valley to synthetic biology". Harvard Gazette. May 16, 2017. Retrieved January 19, 2019.
- S2CID 24764847.
- ProQuest 303201897.
- PMID 6091123.
- PMID 3138162.
- S2CID 4358892.
- PMID 7568202.
- S2CID 8932425.
- PMID 14706338.
- S2CID 36685539.
- PMID 24639514.
- PMID 28553941.
- ^ Anon (2019). "Nature Awards give mentors the recognition, funding, and 'street cred' they need". springernature.com. Retrieved May 2, 2023.
- PMID 17875664.
- PMID 21363961.
- PMID 22751502.
- PMID 25418314.
- PMID 21669865.
- PMID 25417166. Retrieved May 7, 2015.
- PMID 22307292.
- PMID 22647231.
- PMID 24288075.
- PMID 28963440.
- PMID 25675518.
- PMID 17158743.
- ^ "Newly Elected Fellows". www.amacad.org. Retrieved May 1, 2017.